Banca de DEFESA: LEONARDO RENE DOS SANTOS CAMPOS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LEONARDO RENE DOS SANTOS CAMPOS
DATE: 08/03/2024
TIME: 09:00
LOCAL: ICe, Sala de aula 0.03
TITLE:

Large-Scale Inference of Evolutionary Roots of Orthologous Genes with the Bridge Algorithm

KEY WORDS:

Evolutionary network reconstruction; Orthologous groups; Evolutionary rooting inference.

PAGES: 75
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Methods for reconstructing evolutionary scenarios are important tools that help to better understand biological systems under the perspective of its origins and evolution. The primary concept for understanding them lies in the relationships established by comparing genomes from different species to form gene families known as Orthologous Groups (OGs). Orthologs are genes from distinct species derived from their last common ancestor (LCA), tipically having similar functions in each organism. By observing the phyletic pattern of an OG in a species tree, it is possible to calculate the LCA where most probably the trait represented by the OG emerged. Although this process can be trivial when applied to a single gene, it remains chalenging for large-scale queries. The bridge algorithm, structured as a R software package, allows to interrogate several hundreds to thousands of OGs at once, assigining evolutionary roots to each OG. This thesis constitutes a comprehensive reference to the method of rooting orthologous genes employed by the bridge algorithm, presenting detailed logic, implementation, accuracy, and performance.

COMMITTEE MEMBERS:
Interno - 2276280 - CESAR RENNO COSTA
Externo ao Programa - 2394627 - EDUARDO BOUTH SEQUERRA - nullPresidente - 1507794 - RODRIGO JULIANI SIQUEIRA DALMOLIN
Externo à Instituição - SÁVIO TORRES DE FARIAS - UFPB
Externo à Instituição - WILFREDO BLANCO FIGUEROLA - UERN