Banca de DEFESA: TAYRONE DE SOUSA MONTEIRO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : TAYRONE DE SOUSA MONTEIRO
DATE: 31/08/2021
TIME: 14:00
LOCAL: meet.google.com/gce-foww-sny
TITLE:

Reverse engineering of medulloblastoma regulatory networks and inference of master regulators

KEY WORDS:

Pediatric Cancer, Systems Biology, Transcription Factor.

PAGES: 75
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Medulloblastoma (MB) is a cancer of the cerebellum occurring most frequently in the pe- diatric population. This tumor is classified into four distinct molecular subgroups (WNT, SHH, group 3 and group 4), each one also presenting unique clinical features. Some medul- loblastoma epigenetic drivers have been reported by some studies, although the inference of regulatory networks and master regulators have been mentioned only once. Here, we inferred the transcriptional regulatory networks of SHH, group 3 and group 4 subgroups and recognized 10 regulatory units as master regulators and differentially methylated regulons, simultaneously, for all investigated subgroups, subsequently named as the “re- gulons of interest”. The activity pattern of these regulons was observed to vary across subgroups. KEGG pathway enrichment analysis was also done, considering the content of all regulons of interest in each regulatory network. Two KEGG terms were found con- comitantly for all investigated subgroups. This work contributes to the comprehension of the medulloblastoma regulome, identifying prospective master regulators, analyzing their methylome and pointing to potential therapeutic targets.

BANKING MEMBERS:
Presidente - 1507794 - RODRIGO JULIANI SIQUEIRA DALMOLIN
Interna - 379.243.700-72 - RITA MARIA CUNHA DE ALMEIDA - UFRGS
Externa à Instituição - MARIALVA SINIGAGLIA - UFRGS