Banca de QUALIFICAÇÃO: THIAGO FELIPE FONSECA NUNES DE OLIVEIRA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : THIAGO FELIPE FONSECA NUNES DE OLIVEIRA
DATE: 31/07/2020
TIME: 15:30
LOCAL: Google Meet
TITLE:

Polygenic risk for schizophrenia: From Paleolithic to the Bronze Age

KEY WORDS:

Schizophrenia, aDNA, PRS, GWAS

PAGES: 25
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Schizophrenia is a serious psychiatric disorder with a heritability of around 70% that strongly interferes with the way the individual perceives the world, invariably generating sociability difficulties with historically negative implications for the individual's fitness. Despite this, a high prevalence of around 1% is reported globally. Thanks to the performance of large GWAS studies and the development of polygenic scores, the polygenic inheritance of psychiatric disorders, especially schizophrenia, has become better understood and has gained clinical relevance in the prediction of phenotypes. At the same time that a decade of accumulation of ancient DNA sequencing data allows us to analyze larger cuts, the study of the evolutionary history of schizophrenia and other psychiatric disorders is possible. In this work we will calculate polygenic scores for schizophrenia from at least 700 complete ancient genomes sequenced dating between 1,500 and 45,000 years, in order to search for signs of selection the scores will be compared with a null model by genetic drift. The distribution patterns of scores and selection signs will be confronted with known periods of disruptive changes in human behavior, such as the paleolithic cognitive revolution, the beginning of religious behavior, the emergence of agriculture and written language. In accordance with the increasingly solid hypothesis of recent emergence for schizophrenia, the hypothesis of high prevalence of schizophrenia will be investigated until the middle of the second millennium BCE inspired by the work The Origin of Consciousness in the Breakdown of the Bicameral Mind by Julian Jaynes.

BANKING MEMBERS:
Presidente - 1660044 - SIDARTA TOLLENDAL GOMES RIBEIRO
Interno - 1939184 - SANDRO JOSE DE SOUZA
Externo à Instituição - KLEBERSON DE OLIVEIRA PORPINO