Banca de DEFESA: VANDECLECIO LIRA DA SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : VANDECLECIO LIRA DA SILVA
DATE: 04/12/2019
TIME: 13:30
LOCAL: Sala B321, IMD
TITLE:

Bioinformatics applied on identification of  cancer/testis genes and their association with prognosis in a pan-cancer analysis.

KEY WORDS:

Bioinformatics, Cancer/Testis, antigens, biomarkers, prognosis.

PAGES: 45
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genome-wide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma. In addition, we contextualized bioinformatics in a big data scenario.

BANKING MEMBERS:
Interno - 1507794 - RODRIGO JULIANI SIQUEIRA DALMOLIN
Presidente - 1939184 - SANDRO JOSE DE SOUZA
Externo à Instituição - SIDNEY EMANUEL BATISTA DOS SANTOS - UFPA
Interna - 2261797 - TIRZAH BRAZ PETTA LAJUS
Externo à Instituição - ÂNDREA KELY CAMPOS RIBEIRO DOS SANTOS - UFPA