Banca de QUALIFICAÇÃO: VANDECLECIO LIRA DA SILVA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : VANDECLECIO LIRA DA SILVA
DATA : 31/03/2018
HORA: 09:00
LOCAL: BioME
TÍTULO:

Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

PALAVRAS-CHAVES:

Cancer/testis. Cancer antigens. Biomarkers. Prognosis

PÁGINAS: 12
GRANDE ÁREA: Ciências Biológicas
ÁREA: Biologia Geral
RESUMO:

Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma.

MEMBROS DA BANCA:
Interno - 2276280 - CESAR RENNO COSTA
Interno - 2170415 - JORGE ESTEFANO SANTANA DE SOUZA
Presidente - 1939184 - SANDRO JOSE DE SOUZA