Banca de QUALIFICAÇÃO: FELIPE DE LIMA ALMEIDA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : FELIPE DE LIMA ALMEIDA
DATA : 13/03/2018
HORA: 14:00
LOCAL: BioME
TÍTULO:

The central role of CDC48 protein: a network based on the response to oxidative stress in Saccharum spp.

 

PALAVRAS-CHAVES:

Saccharum spp. Hydrogen peroxide. Oxidative stress. Response to stress. Systems biology.

PÁGINAS: 55
GRANDE ÁREA: Ciências Biológicas
ÁREA: Biologia Geral
RESUMO:

Oxidative stress in plants involves a number of signaling mechanisms derived from a networked organization, and the H2O2 molecule accumulation promotes different metabolic effects that may compromise the plant development. In this study from 6 proteins associated with the H2O2 stress response obtained through shotgun proteomic analysis, we used bioinformatics resources and tools in systems biology to identify signaling pathways associated with response by exogenous treatment with H2O2 in Saccharum spp. roots. Through the construction of a protein-protein interaction network and its analysis of ontology and network topologies it was possible to identify pathways associated with sugars, suggesting Trehalose-6-Phosphate (T6P) as a specific role for sucrose and regulating the use of such sugar in the plant. In addition, taking as assumption the centrality of the constituent proteins of the network, we identified CDC48 as the only central point that has multiple interface with the other proteins in the network, forming protein complexes and modules that are associated with the Endoplasmic Reticulum Associated Degradation (ERAD) that act to reduce the stress effects promoted by H2O2 accumulation in the Endoplasmic Reticulum (RE), removing to the proteasome unfolfed / misfolded proteins that would impair the plant development. These regulatory responses besides contributing to acclimatization of the plant in the environment, provide subsidies for the clarification of the interactions between oxidative response systems in sugarcane.

MEMBROS DA BANCA:
Interno - 1893445 - EUZEBIO GUIMARAES BARBOSA
Presidente - 1513597 - JOAO PAULO MATOS SANTOS LIMA
Interno - 1507794 - RODRIGO JULIANI SIQUEIRA DALMOLIN