Banca de DEFESA: CRISTIANE NIKELY SILVA PALMEIRA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : CRISTIANE NIKELY SILVA PALMEIRA
DATE: 13/09/2023
TIME: 08:30
LOCAL: Anfiteatro das Aves, CB/UFRN
TITLE:

AMPHIBIANS AS BIOINDICATORS OF EXPOSURE TO EMERGING DRUGS: INTERDISCIPLINARY PERSPECTIVES

KEY WORDS:

Anuran amphibians; Emerging contaminants; carbamazepine; Environmental perception; toxicity

PAGES: 151
BIG AREA: Outra
AREA: Ciências Ambientais
SUMMARY:

Environmental pollution from the use of chemical substances is considered a direct threat to biodiversity. The release of different types of organic and inorganic pollutants through wastewater, including pharmaceutical products, is resulting in several environmental impacts and some drugs are already considered toxic to aquatic animals. Therefore, this work had the following objectives: (i) to verify the literature in search of information about the impacts of pharmaceutical compounds on the development and survival of amphibians, through the analysis of articles that evaluated the lethal and sublethal effects caused by these xenobiotics; (ii) investigate and evaluate the effects of the drug carbamazepine (CBZ) using frog tadpoles of the species Physalaemus cuvieri (Leptodactylidae), as a source of biomarkers enabling advances in the knowledge of the actions of pharmaceutical products on non-target organisms and their negative impacts on the ecosystem ; (iii) Collect and evaluate information about the perceptions of risk by undergraduate students of the Biological Sciences course at the Federal University of Rio Grande do Norte (UFRN). For the objectives, the methodologies were adopted: (i) a bibliographic review was carried out through consultations to databases; (ii) P. cuvieri tadpoles were exposed to CBZ via water for four and ten days. After the exposure period, parameters were observed to evaluate biomarkers, such as mortality, morphology, genotoxicity, feeding and behavior in these tadpoles; and (iii) an online questionnaire was sent through the UFRN computer system to the e-mails of students of the Biological Sciences course, Natal/RN campus. The results showed that (i) different species of amphibians were used and exposed to some categories of pharmaceutical products, in which these substances induced pathological changes at the cellular level, in physiology, morphology and in different types of behavior, such as: feeding and reproductive , in these animals. Some substances have been shown to be lethal and others have resulted in negative but limited biological changes. In (ii), P. cuvieri tadpoles represent a sensitive tool for ecotoxicological studies. Wherein, CBZ was able to promote developmental and behavioral toxic effects in tadpoles at environmentally relevant concentrations. As for the UFRN Biological Sciences students (iii), the interviewees have a high level of knowledge about issues related to the problems faced by the environment in relation to the incorrect disposal of medicines and its consequences for nature. In general, drugs pose an environmental risk to aquatic animals, especially amphibians. Tests with CBZ showed that at environmentally relevant concentrations, the drug caused mortality, decreased feeding activity and behavioral alteration in P. cuvieri. And the biological sciences students at UFRN had a good perception of the impacts caused by drugs and environmental risks. Finally, the environmental problems caused by medicines result from inadequate urban planning, poor sanitation, degraded infrastructure and pollution, posing significant challenges to unique health.

COMMITTEE MEMBERS:
Externa ao Programa - 1644341 - ANA CAROLINA LUCHIARI - UFRNInterna - 2380571 - CIBELE SOARES PONTES
Externa à Instituição - MARIA CRISTINA BASÍLIO CRISPIM DA SILVA - UFPB
Externo à Instituição - MIGUEL FERNANDES KOLODIUK - IFRN
Presidente - 1674709 - VIVIANE SOUZA DO AMARAL