Banca de QUALIFICAÇÃO: URSULA THAIS DE PAULA MEDEIROS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : URSULA THAIS DE PAULA MEDEIROS
DATE: 29/06/2022
TIME: 14:30
LOCAL: Videoconferência via Google Meet (https://meet.google.com/xtg-dhbw-anh)
TITLE:

EMERGING CONTAMINANTS IN DOMESTIC SEWAGE TREATMENT SYSTEMS: IMPACT OF CARBAMAZEPINE ON HEALTH AND THE ENVIRONMENT.

KEY WORDS:

Emerging contaminants; drug; carbamazepine; effluents; toxicity

PAGES: 100
BIG AREA: Outra
AREA: Ciências Ambientais
SUMMARY:

An Update on Emerging Organic Contaminants of Concern for New Zealand with Guidance on Monitoring Approaches for Councils (2016) Micropollutants are unmonitored or environmentally legislated contaminants that can affect the quality of aquatic ecosystems worldwide. This group of pollutants includes a variety of substances up to pharmaceuticals. Sewage treatment systems aim to reduce or eliminate the polluting load. Different technologies have been developed and implemented for this purpose. However, there are still few studies on the ability to remove these micropollutants. Substances such as drugs and/or their metabolites may have biological action even at low concentrations. Thus, ecotoxicological studies support a global view of the biological effect linked to a substance or complex environmental sample. Studies linking the occurrence of drugs in treated domestic effluents and the biological representation of the consequences arising from environmental exposure are essential to understand ecological risks and potential threats to public health. In this work, we observed the presence of a psychoactive drug, carbamazepine, which is widely used by various populations in the 5 continents of the world. Despite the extensive use of this compound, there is a lack of information on genetic toxicity, which makes the indirect consumption of this substance, through the aquatic matrix, a risk for populations. Given this context, the present work aimed to investigate the toxic potential of CBZ, at the cellular level. Assays in HepG2 cells for the evaluation of cytotoxicity, genotoxicity, and mutagenicity were carried out, in addition to discussing the advances and challenges for the implementation of regulations to establish limits for the release of drugs into the environment through the action of this compound in the different stages of the so-called urban cycle of water use, mainly involving the disposal of these compounds through domestic effluents and the contribution to water bodies from surface runoff. Finally, still in this scenario, it was observed that the regional councils carry out several monitoring programs to assess the state of the environment, to understand the environmental status and trends and to measure the effectiveness of policies and plans, but these monitoring programs do not these include drugs, as in Brazil. However, evidence shows that some of these substances can cause deleterious environmental effects. Without a national strategy on micropollutants such as pharmaceuticals, it is necessary for each regional council to provide its own impetus to ensure that they are meeting their environmental protection obligations.

COMMITTEE MEMBERS:
Presidente - 1674709 - VIVIANE SOUZA DO AMARAL
Interna - 2380571 - CIBELE SOARES PONTES
Externa ao Programa - 2190974 - JOANA DARC FREIRE DE MEDEIROS - UFRNExterna à Instituição - MÔNICA TEJO CAVALCANTI - UFCG