Banca de DEFESA: RODRIGO THIAGO DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RODRIGO THIAGO DA SILVA
DATE: 12/11/2021
TIME: 08:30
LOCAL: Videoconferência
TITLE:

EFFECTS OF SUCROSE EXPOSURE AND WITHDRAWAL ON ANXIETY-RELATED BEHAVIORS IN ADOLESCENT RATS

KEY WORDS:

sugar, abstinence, anxiety, adolescence

PAGES: 66
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUBÁREA: Neuropsicofarmacologia
SUMMARY:

Adolescence is a critical period for the development of the central nervous system (CNS) and neuronal plasticity processes may be sensitive to environmental challenges. Evidence shows that exposure to sucrose affects brain development, even promoting behavioral changes. The aim of this study was to test the hypothesis that sucrose exposure and withdrawal alter anxiety-related behaviors in adolescent rats. Thirty-days-old Wistar rats obtained from the Animal Facility of the Biosciences Center – UFRN received water and feed ad libitum throughout the experimental period. Animals divided in the following groups were submitted to the elevated plus maze test (EPM) for 5 minutes, individually: control group (animals that received water as a source of liquid throughout the experiment), sucrose group (animals that received sucrose 5% as an additional source of liquid for 16 days, with access to sucrose until the day of the EPM test), short-term withdrawal group (animals that received sucrose 5% as an additional source of liquid for 16 days, with sucrose replaced by water 48 hours prior to the EPM test) and the long-term withdrawal group (animals that received sucrose 5% as an additional source of liquid for 16 days, with sucrose replaced by water 21 days prior to testing in the EPM). Twenty-four hours after the test in the EPM, the animals of all experimental groups were submitted to the open field test. The results showed that the exposure as well as the removal of sucrose in adolescent rats did not alter anxiety-related behaviors in the EPM and in the open field tests.

BANKING MEMBERS:
Externa ao Programa - 1519121 - MANUELA DOS SANTOS CARVALHO SCHIAVON
Externo à Instituição - RAMÓN HYPOLITO LIMA - IIN-ELS
Externa ao Programa - 1720860 - VANESSA DE PAULA SOARES RACHETTI