Banca de QUALIFICAÇÃO: LUIZ HENRIQUE COSTA DE MEDEIROS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LUIZ HENRIQUE COSTA DE MEDEIROS
DATE: 11/11/2019
TIME: 14:00
LOCAL: Sala Carl Peter von Dietrich - Departamento de Bioquímica
TITLE:

Antioxidant potential of the Chondroitin sulfate extracted from the viscera of oreochromis niloticus

KEY WORDS:

Chondroitin sulfate, Oreochromis niloticus, antioxidant, anti-inflammatory, ROS, proteoglycans.

PAGES: 49
BIG AREA: Ciências Biológicas
AREA: Bioquímica
SUMMARY:

Glycosaminoglycans are polysaccharides present in the cell surface and extracellular matrix of the vast majority of animals. They perform several biological functions, such as cell growth, differentiation, antioxidant, neuroprotec and others. Among glycosaminoglycans, chondroitin sulfate (CS) stands out for its antioxidant effect and can also be found in marine animal tissues, such as tilapia (Oreochromis niloticus) whose cultivation represents an important economic activity in Natal (RN / Brazil). ), eliminating a big quantity of viscera as a waste of its production, daily. Thus, the following study wants to use these tilapiculture wastes as raw material for chondroitin sulfate production and the evaluation of its antioxidant effect, to quantify its possible use as a protector of oxidative stress, which has an important participation in the development of diseases such as autoimmunities. For this, the viscera were submitted to enzymatic degradation and chromatography processes, and their final result was exposed to antioxidant tests such as ferric ion chelation and DCFH-DA. The results show that CS extracted from the tilapia viscera is able to act as an antioxidant in several ways, highlighting the inhibition of intracellular reactive species. These data open expectations for possible uses of this molecule in research and industry.

BANKING MEMBERS:
Presidente - 2195251 - HUGO ALEXANDRE DE OLIVEIRA ROCHA
Interna - 3315429 - LUCIANA GUIMARAES ALVES FILGUEIRA
Interno - 2213126 - VALTER FERREIRA DE ANDRADE NETO