Banca de DEFESA: KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES
DATA : 10/06/2016
HORA: 10:00
LOCAL: Sala Imburana - Centro de Biociências
TÍTULO:

VITAMIN E BIOCHEMICAL NUTRITIONAL STATUS  OF MOTHERS AND CHILDREN PRETERM AND TERM  FROM BIRTH TO 3 MONTHS POSTPARTUM

PALAVRAS-CHAVES:

Alpha-tocopherol. Preterm. Human milk. Lactating. Breastfeeding. Vitamin E deficiency

PÁGINAS: 141
GRANDE ÁREA: Ciências Biológicas
ÁREA: Bioquímica
RESUMO:

Vitamin E is a fat-soluble antioxidant micronutrient extremely important for preterm newborns (<37 weeks gestation) since it protects the central nervous system and prevents hemolytic anemia and bronchopulmonary dysplasia. Due to its limited placental transfer, the provision of vitamin E to the infant through breast milk is essential to ensure an adequate supply and to prevent/correct deficiencies. There is limited data on the vitamin E recovery in infants through the lactation period and the composition of alpha-tocopherol in preterm milk. This study aimed to evaluate the vitamin E nutritional status in women, preterm and term infants from birth to 3 months postnatal, their relationships, the concentration of alpha-tocopherol in breast milk and the possible vitamin intake of infants. A prospective study was initially conducted with 235 postpartum women and infants attending two public maternity hospitals in Rio Grande do Norte, Brazil, 124 allocated in the preterm group and 111 in the term group (≥ 37 weeks), for three months postpartum. Colostrum, maternal blood and umbilical cord were collected up to 48 hours after delivery. Breast milk and dietary data were collected at 7, 30 and 90 days postpartum, as weel as maternal and children’s blood at day 90. Alpha-tocopherol was analyzed by High Performance Liquid Chromatography and vitamin E dietary intake of women and infants were analyzed according to consumption recommendations for the age group. The concentration of maternal serum alpha-tocopherol was not different between the groups, and an increase in vitamin E deficiency was found (< 517 μg/dL) through lactation (from 8.6% to 22.2%), reaching 789.6 (313.1) μg/dL in the preterm group and 875.3 (341.6) μg/dL in the term group (p=0.197), evidencing 100% of dietary inadequacy of vitamin E during lactation (< 16 mg/day). Over 90% of infants presented low alpha-tocopherol levels at birth (< 500 μg/dL), and at day 90 the mean concentration of serum alpha-tocoferol was 583.3 (209.4) μg/dL in the preterm group and 884.4 (458.8) μg/dL in the term group (p < 0.007), evidencing 44.4% and 21.4% of inadequate levels (< 517 μg/dL), respectively. There was a positive association in serum levels between the mother and the infant (p < 0.003). In the preterm group, alpha-tocopherol levels were lower in colostrum, yet higher in transitional and mature milk (day 30), in comparison to the term group (p < 0.0001). Only mature milk did not provide the vitamin E amount recommended for infants (> 4 mg/day). Thus, it was found a high inadequacy of vitamin E at 3 months postpartum in both women and preterm children, differences in preterm milk composition and a possible limited vitamin supply by mature milk, highlighting the need of greater nutritional assistance during lactation, especially due to vitamin E deficiency and its effects on children's cognitive development.

MEMBROS DA BANCA:
Externo ao Programa - 2646462 - BRUNA LEAL LIMA MACIEL
Interno - 1880243 - DANIEL CARLOS FERREIRA LANZA
Externo à Instituição - MARILIA DA SILVA NASCIMENTO SANTOS - IFRN
Externo à Instituição - MONICA MARIA OSORIO DE CERQUEIRA - UFPE
Presidente - 180.956.404-25 - ROBERTO DIMENSTEIN - UFRJ