CONTAMINATION BY PHARMACEUTICAL COMPOUNDS IN AN URBANIZING FLUVIAL-LAGOON SYSTEM
Pharmaceutical compounds; Emerging Micropollutants; Caffeine; Ivermectin; Liquid chromatography
Despite numerous studies on the occurrence of drugs worldwide, there is a shortage of these data in Brazil, which are mostly restricted to the southeastern region. Due to the inherent climatic, demographic and social variations of each Brazilian region, the need for studies covering hydrographic basins located in other regions of the country is demonstrated. This information is necessary to assess risk management and regulation concerning pharmaceutical contamination and contribute to a greater understanding of the occurrence of drugs in developing countries. Thus, this study aims to investigate the occurrence of pharmaceutical compounds in the lagoon-river system, Pitimbu River and Jiqui Lagoon / RN, used for urban supply, in order to quantify concentrations and observe the spatial variability of pollutants in the system, using geoprocessing techniques to map land use and occupation, aiming at recognizing possible sources of contamination in an area of urban expansion and densification. In this study, four drugs (Caffeine, Genfibrozil, Ibuprofen and Ivermectin) would be evaluated in eight collection campaigns in two sections of the Pitimbu River basin. The compounds would be concentrated by the solid phase extraction method and detected and quantified by liquid chromatography coupled with tandem mass spectrometry (SPE-LC-ESI-MS/MS). In possession of the results, correlation analysis would be carried out to understand whether the characteristics of land use and occupation and increasing population density are related to the detected concentrations.