Banca de DEFESA: MATHEUS MIGUEL SOARES DE MEDEIROS LIMA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MATHEUS MIGUEL SOARES DE MEDEIROS LIMA
DATE: 27/09/2024
TIME: 10:00
LOCAL: Google Meet, meet.google.com/bgb-evwu-wzu
TITLE:

Investigating the Taxonomy of Enterococcus casseliflavus and Related Species

KEY WORDS:

Enterococcus; Taxonomy; ANI; Pangenome.

PAGES: 45
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Enterococcus casseliflavus, a commonly motile, yellow-colored bacterium, is a commensal member of the gastrointestinal tract. It is occasionally found in cases of bacteremia and other human infections. One concern is that all strains of this species have the vanC gene cluster on their chromosome, which confers resistance to vancomycin. The classification of E. casseliflavus is challenging, as it presents 99% identity in the 16S analysis with E. gallinarum and, mainly, with E. flavescens, being often classified as a single species. The goal of this study was to investigate the taxonomy of E. casseliflavus and other related species by analyzing genomic data available in public databases. For this purpose, 155 genomes of species related to E. casseliflavus (E. casseliflavus, E. flavescens, E. entomosocium and E. innesii) were rescued and subjected to Average Nucleotide Identity (ANI), pangenome and phylogenomic analysis. The approaches showed three well-defined groups corresponding to three species of Enterococcus (E. casseliflavus, E. flavescens and E. innesii). With characteristics of an open pangenome, the group showed great conservation of core genes and high accessory genome diversity. Here we suggest removing the synonymous species status between the species E. flavescens and E. casseliflavus and adding the synonymous species status between E. entomosocium and E. casseliflavus.

COMMITTEE MEMBERS:
Presidente - 3063244 - TETSU SAKAMOTO
Interna - 1149647 - LUCYMARA FASSARELLA AGNEZ LIMA
Externa à Instituição - FLÁVIA FIGUEIRA ABURJAILE - UFMG
Externa à Instituição - JANIRA PRICHULA