Banca de QUALIFICAÇÃO: SABRINA KAROLAINE ARAÚJO SOUSA DE LIMA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : SABRINA KAROLAINE ARAÚJO SOUSA DE LIMA
DATE: 30/08/2024
TIME: 09:00
LOCAL: Google Meet, https://meet.google.com/hiu-pfst-nsm
TITLE:

Study of the Population Structure of Treponema pallidum subsp. pertenue from Infections in Humans and Non-Human Primates.


KEY WORDS:

Admixture; Yaws; Population Structure; Genome; Pertenue; Treponema pallidum.


PAGES: 10
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Treponema pallidum, a bacterium from the phylum Spirochaetota, is responsible for treponematoses, diseases caused by different subspecies of this bacterium, each associated with specific infections. This study focuses on Treponema pallidum subsp. pertenue (TPE), which causes yaws in humans, a disease primarily transmitted through direct contact with skin lesions, predominantly affecting children and pre-adolescents. If left untreated, it can lead to severe deformities in bones and cartilage. During the XX century, significant progress was made in the eradication and control of this subspecies; however, in recent decades, an increase in the number of reported cases has been observed. Until recently, it was believed that this subspecies only affected humans, but recent studies have identified that non-human primates (NHPs) have also been naturally infected by TPE. Given the growing impact of this disease on both humans and other species, TPE has become a critical focus for monitoring and scientific research. This study aims to clarify the relationship between infection in humans and other primate species, contributing to a better understanding of transmission dynamics and potential control and prevention strategies. To achieve this, we utilized genome sequences from 58 TPEs available in public repositories and the ADMIXTURE tool, which allowed us to examine the occurrence of genetic mixing between populations that infect humans and primates. These analyses are crucial for deepening our understanding of the disease’s spread and its interaction between different species.


COMMITTEE MEMBERS:
Presidente - 3063244 - TETSU SAKAMOTO
Interno - 1513597 - JOAO PAULO MATOS SANTOS LIMA
Notícia cadastrada em: 23/08/2024 12:04
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