Banca de DEFESA: KEZIA MARIA DA SILVA BARROS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : KEZIA MARIA DA SILVA BARROS
DATE: 30/08/2024
TIME: 14:00
LOCAL: sala de videoconferência no Centro de Convivência
TITLE:

Association between toxoplasmosis and pre and postpartum depression in
women living in the municipality of SANTA CRUZ - RN

KEY WORDS:

Toxoplasmosis, postpartum depression, puerperium, risk factor.

PAGES: 80
BIG AREA: Ciências Biológicas
AREA: Parasitologia
SUMMARY:

Toxoplasmosis, a disease caused by the protozoan Toxoplasma gondii, is a zoonosis with worldwide geographic distribution, affecting all continents, even in the face of climate variations. Clinical manifestations are mild or, in many cases, subclinical in a large part of the population. However, severe cases occur in immunocompromised individuals and also in pregnant women due to vertical transmission due to the damage it can cause to the development of the newborn. In addition, it has been demonstrated that latent toxoplasmosis is associated with behavioral changes and neuropsychiatric disorders. In view of this, we evaluated the hypothesis of a correlation between T. gondii infection and pre- and postpartum depression. In this study, a cross-sectional population-based survey was conducted targeting women aged 15 to 45 years, living in the city of Santa Cruz, in the interior of the state of Rio Grande do Norte, who were assessed at two time points: at the end of the 3rd trimester of pregnancy and after delivery. Pregnant women were approached at the 5 (five) UBS (basic health units) distributed throughout the city, and 30 days after the expected date of delivery, they were contacted again for a second interview. To assess depressive symptoms, we used the Edinburgh Postnatal Depression Scale (EPDS), an instrument containing 10 questions, validated for use during pregnancy and the postpartum period. To identify the profile and epidemiological aspects of toxoplasmosis, a sociodemographic questionnaire structured for this study was used. Data were tabulated in the Epidata program and analyzed using STATA. Of the 78 interviewees, 24 (30.77%) pregnant women had positive serology for chronic toxoplasmosis, and 54 (69.23%) were seronegative, indicating a large percentage of women susceptible to infection by the protozoan. And associating the two clinical conditions, positive IgG serology (infected) and predisposition to depression 10 (41.66%) were found, with 8 (33.33%) without diagnoses of other disorders until pregnancy. A greater predisposition to depressive symptoms (according to the EPDS scale) was observed in the postpartum period 17 (62.96%) compared to the prepartum period 10 (37.03%), characterizing greater vulnerability in the puerperium. The statistical analysis showed a correlation between the areas where the UBS were located and the prevalence of toxoplasmosis, with a higher percentage for Paraiso 8 (34.78%) and Maracujá 8 (50.00%) compared to the other neighborhoods, although it did not show a significant difference in relation to the income variable, this may be associated with the socioeconomic conditions present in these two areas. The high level of education in this population demonstrated a risk factor for the prevalence of toxoplasmosis. Therefore, given the number of women at risk for toxoplasmosis, the development of depressive symptoms during pregnancy and the postpartum period, and the lack of knowledge about the disease and prophylaxis, further investigation into the development of pre- and postpartum depression associated with toxoplasmosis is necessary, as well as the implementation of health education programs for understanding, prevention, and screening.

COMMITTEE MEMBERS:
Externo à Instituição - AROLDO JOSÉ BORGES CARNEIRO
Externa ao Programa - 3575538 - DEBORA DE ALMEIDA ALOISE - nullInterna - 1714262 - LILIAN GIOTTO ZAROS DE MEDEIROS
Presidente - 2213126 - VALTER FERREIRA DE ANDRADE NETO