Banca de QUALIFICAÇÃO: MARIA FATIMA DE AZEVEDO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARIA FATIMA DE AZEVEDO
DATE: 04/08/2026
TIME: 08:30
LOCAL: REMOTA - https://meet.google.com/crc-pkxs-vat
TITLE:

EXPLORING 24-HOUR AMBULATORY BLOOD PRESSURE IN WOMEN WITH PCOS: COMPARISON WITH OVULATORY CONTROLS AND ASSOCIATED FACTORS

KEY WORDS:

polycystic ovary syndrome, blood pressure, cardiovascular disease, cardiometabolic risk, body mass index.

PAGES: 14
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Objective: To compare 24-hour ambulatory blood pressure (ABP) between women with polycystic ovary syndrome (PCOS) and ovulatory controls, and to explore potential anthropometric, hormonal, metabolic, and inflammatory correlates of ABP in women with PCOS.

Methods: In this cross-sectional study, 50 women with PCOS (diagnosed by Rotterdam criteria) and 50 ovulatory controls underwent office and 24-hour ABP monitoring. Clinical, anthropometric, hormonal, metabolic, and inflammatory parameters were assessed. Between-group comparisons were adjusted for BMI. LASSO regression was used to identify variables independently associated with ABP in the PCOS group.

Results: Women with PCOS showed significantly higher 24-hour and daytime mean arterial pressure and heart rate compared to controls, even after adjustment for body mass index (BMI) (p<0.05). No differences were observed in nighttime ABP (p>0.05). PCOS participants also exhibited a more adverse cardiometabolic profile, including higher BMI, waist circumference, insulin, HbA1c, triglycerides, creatinine, and TNF-alfa, along with lower estradiol and progesterone levels. In LASSO models, BMI emerged as the only consistent independent predictor of ABP across all periods. Additional predictors, such as HbA1c (nighttime mean BP), creatinine (daytime diastolic BP), and waist circumference (daytime systolic BP), were retained in specific models, while most hormonal, metabolic, and inflammatory markers were not associated with ABP outcomes in the PCOS group.

Conclusion: Women with PCOS exhibit higher 24-hour and daytime ABP compared to ovulatory controls, independently of BMI. Adiposity, as assessed by BMI, appears to be the dominant factor associated with ABP in this population. These findings highlight the importance of 24-hour ABP monitoring and weight management in the cardiovascular risk assessment and care of women with PCOS.

COMMITTEE MEMBERS:
Interna - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Presidente - 2682821 - EDUARDO CALDAS COSTA
Externa ao Programa - 2786809 - MARIA THEREZA ALBUQUERQUE BARBOSA CABRAL MICUSSI - null