Banca de QUALIFICAÇÃO: ROXANE RAFAELA MACEDO DOS SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: ROXANE RAFAELA MACEDO DOS SANTOS
DATA: 31/10/2013
HORA: 10:30
LOCAL: SALA DE AULA 01 - PPGCSA
TÍTULO:

Effects of licorice (Glycyrrhiza uralensis F.) commercial extract on the biodistribution of the radiopharmaceutical sodium pertechnetate, radiolabeling of blood constituents and on some biochemical parameters in Wistar rats

PALAVRAS-CHAVES:

Licorice, Glycyrrhiza uralensis, biodistribution, radiopharmaceutical, sodium pertechnetate, interaction, rats.

PÁGINAS: 7
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

This study investigated the influence of a licorice (Glycyrrhiza uralensis) commercial extract on the biodistribution of the radiopharmaceutical sodium pertechnetate, on the radiolabeling of blood constituents and on selected biochemical parameters of Wistar rats. The animals were treated with licorice for 7 days and the assays were performed. A biodistribution assay was performed by administering sodium pertechnetate and determining its activity in organs and tissues. Blood samples were also withdrawn from the animals, the radiolabeling procedure was carried out and the biochemical parameters determined. A decrease of the radiopharmaceutical uptake was found in bladder and testis. No changes on the radiolabeling of the blood constituents neither on the biochemical parameters were found. In conclusion, licorice showed effect on the biodistribution of the sodium pertechnetate in rats. Moreover, as the licorice has not interfered on the Technetium-99m (99mTc)-radiolabeling of blood constituents (depends on the presence of a reducing agent), this finding reinforces the antioxidant property of the licorice. Although this study was carried out with rats treated with licorice commercial extract, a precaution is suggested in the interpretation of nuclear medicine examinations with the radiopharmaceutical sodium pertechnetate involving the excretory system in patients that are undertaking licorice

MEMBROS DA BANCA:
Interno - 346138 - ALDO DA CUNHA MEDEIROS
Presidente - 347795 - IVONETE BATISTA DE ARAUJO
Externo à Instituição - PATRICIA FROES MEYER - UnP