Banca de DEFESA: AMADEU CLEMENTINO ARAUJO NETO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : AMADEU CLEMENTINO ARAUJO NETO
DATE: 28/07/2023
TIME: 09:00
LOCAL: Videoconferência via PPGDem/UFRN
TITLE:

Ovarian cancer mortality from a demographic perspective

KEY WORDS:

Ovarian cancer; reproductive behavior; demography; effect of age, period and cohort; Logistic models

PAGES: 60
BIG AREA: Ciências Sociais Aplicadas
AREA: Demografia
SUMMARY:

Ovarian cancer is highly associated with changes in women's reproductive behavior, becoming the seventh most incident cancer and the eighth cause of cancer death in women. At the population level, the differentials in the incidence and mortality from this neoplasm are correlated with the population's age structure, especially with population aging and the reduction in the fertility rate. Notably, reproductive factors (nulliparity, not using oral contraceptives, never having breastfed) are responsible for more than 80% of the population's attributable risk of ovarian cancer. The temporal evolution of the incidence and mortality of health problems is influenced by three temporal factors: age, period, and cohort. Thus, the present dissertation aims to evaluate the effect of age, period, and cohort in Brazilian states that present essential differences in the reproductive behavior of women, Federation Units of the Northeast and South of the country, for mortality from ovarian cancer, in the period of 1980 to 2019, in the age group of 30 to 80 years. Death records will be extracted from the Mortality Information System (SIM/DATASUS), and population data will be obtained from the Brazilian Institute of Statistics and Geography (IBGE). In order to obtain more reliable mortality rates, the quality and coverage of deaths were corrected. After correcting the deaths, crude mortality rates were calculated, specific by age group, and standardized by the direct method, using the world population proposed by Segi as the standard population. The APC effects were calculated for mortality rates in the five years from 1980-1984 to 2010-2019, using Poisson regression using estimable functions proposed by Holford and implemented by Carstensen. During the study period, the average mortality rate per 100,000 women in the South region was 7.60, and in the Northeast, 5.25. The highest average rates were observed in the states of Rio Grande do Sul (8.09/100,000 women) and Santa Catarina (7.50/100,000 women) and the lowest in Paraíba (3.99/100,000 women) and in Alagoas (4.48/100,000 women). Differences were observed in the risk of death in the 2000s between the states of the South and Northeast regions, with an increase in the last five years in states of the Northeast region and a reduction in the states of the South. Furthermore, there was an increase in the risk of death from ovarian cancer in women of generations born from the 1950s onwards. Differences in the period effect observed between the states of these two regions may be correlated with inequalities in access to health services from Primary Care to highly complex treatment in oncology. Moreover, the increased risk of ovarian cancer mortality in younger generations correlates with changes in reproductive behavior and the westernization of lifestyle habits.

COMMITTEE MEMBERS:
Interna - 1225734 - JORDANA CRISTINA DE JESUS
Externo à Instituição - JULIANO DOS SANTOS - INCA
Presidente - 1855608 - KARINA CARDOSO MEIRA