Banca de DEFESA: CRISTINA MARIA DE ARAUJO MEDEIROS SANTOS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : CRISTINA MARIA DE ARAUJO MEDEIROS SANTOS
DATE: 30/03/2026
TIME: 09:00
LOCAL: Videoconferência
TITLE:

IMPACTO DE UMA DIETA ANTI INFLAMATÓRIA NA MODULAÇÃO DE CITOCINAS E QUALIDADE DE VIDA EM MULHERES COM ENDOMETRIOSE EM USO DE DIENOGESTE

KEY WORDS:

Endometriosis; Dienogest; Anti-inflammatory diet; Cytokines;

PAGES: 138
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

This study aims to evaluate the role of an anti-inflammatory diet, correlating it with the inflammatory response profile and quality of life factors in women with endometriosis using dienogest. In this study, 82 women were stratified in the endometriosis outpatient clinic of a tertiary university hospital. Blood samples were collected by venipuncture for quantification of pro-inflammatory cytokines using flow cytometry with the CBA inflammation kit (Human Inflammatory Cytokines Kit: IL-8, IL-1, IL-6, IL-10, TNF, IL-12p70 – Catalog 551811, Becton Dickinson Biosciences Pharmingen, BD, San Diego, CA, USA) at baseline and after a 6-month follow-up using an anti-inflammatory diet. Furthermore, validated instruments such as the EHP-30 and GSRS were used to assess quality of life.

The analyses were performed using the Shapiro-Wilk normality test, which was applied to verify the adherence of quantitative variables to a normal distribution. Descriptive analysis of variables that adhered to a normal distribution was performed using the mean and standard deviation (Mean ± SD). For variables that did not present a normal distribution in at least one of the groups, the median and interquartile range (IQR) were used. Categorical variables were analyzed using absolute and relative frequencies.

Analysis of biochemical and dietary parameters revealed statistically significant reductions in median values of blood glucose, glycated hemoglobin, total cholesterol, triglycerides, aspartate aminotransferase, and alanine aminotransferase after adherence to the diet, with moderate effects (0.434 ≤ r ≤ 0.737). A significant increase in vitamin D levels was also observed (p = 0.003, r = 0.467). No statistically significant differences were observed between women who used dienogest and those who did not in biochemical markers, IID, and diet adherence score, before or after the intervention (p > 0.05). Both groups showed improvements with the diet, suggesting that the use of dienogest did not influence the metabolic and inflammatory response to the intervention.

After intervention with the anti-inflammatory diet, a significant improvement was observed in almost all domains assessed by the EHP-30.

Subsequently, these data were correlated with the sociodemographic, clinical, and laboratory data of these patients. The evaluation of the mechanisms related to the pathophysiology of endometriosis brings an innovative approach within the scientific universe and, in this way, will expand scientific knowledge about the discovery of biomarkers as a tool for diagnosis, prognosis, and/or treatment of endometriosis.

The results suggest that the anti-inflammatory diet generated an inflammatory index independent of the use of dienogest and had a positive impact, with significant improvement in most domains assessed by the validated EHP-30 instrument.

COMMITTEE MEMBERS:
Presidente - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS
Externo à Instituição - JOSE MARIA SOARES JUNIOR - USP
Externa ao Programa - 3146620 - MANUELA SALES LIMA NASCIMENTO - UFRNExterno ao Programa - 1544647 - MATHEUS DE FREITAS FERNANDES PEDROSA - UFRNExterna à Instituição - PAULA ANDREA DE ALBUQUERQUE SALLES NAVARRO - USP