Banca de DEFESA: VIVIAN FERNANDA DANTAS DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : VIVIAN FERNANDA DANTAS DA SILVA
DATE: 21/09/2026
TIME: 08:00
LOCAL: Google Meet
TITLE:

ACNE VULGARIS AND THERAPEUTIC MANAGEMENT DURING PREGNANCY AND THE PUERPERIUM

KEY WORDS:

Acne vulgaris. Pregnancy. Postpartum period. Treatment. Microneedling. Plasma jet. Acne scars. Puerperium.

PAGES: 77
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

INTRODUCTION: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit, with high prevalence and a relevant physical, psychological, and social impact. Although primarily associated with adolescence, AV is clinically important in women of reproductive age, particularly during the pregnancy–postpartum period, which is characterized by hormonal and physiological changes that may influence disease progression. The management of AV during pregnancy and lactation is challenging due to therapeutic limitations related to maternal, fetal, and neonatal safety, while its sequelae, such as atrophic scars, may negatively affect self-esteem and quality of life. OBJECTIVE: This dissertation aimed to investigate the management of acne vulgaris in women's health, addressing treatment during pregnancy and the postpartum/lactation period, as well as therapeutic approaches for post-acne scars in the post-pregnancy period. METHODS/RESULTS: Two complementary studies were developed. The first was a scoping review conducted according to the recommendations of the Joanna Briggs Institute (JBI) and PRISMA-ScR, including studies on the treatment of AV during pregnancy and lactation. Five studies published between 2011 and 2025 were identified, demonstrating a predominance of topical therapies, such as azelaic acid, clindamycin, and erythromycin, in addition to selected interventions, including systemic antibiotics, phototherapy, and photodynamic therapy. However, the available evidence is of low quality, with no randomized clinical trials identified. The second study was a randomized, prospective, controlled clinical trial protocol with a blinded assessor and split-face design, developed according to SPIRIT recommendations. Fifty-one women aged 18–35 years, with atrophic scars secondary to pregnancy-related acne and at least six months postpartum, will be included. Each participant will undergo microneedling on one hemiface and plasma jet therapy on the other, with assessments at baseline, immediately after the procedure, and at 21 and 90 days. The primary outcome will be scar reduction, while secondary outcomes will include pain, participant preference, perceived clinical improvement, quality of life, and adverse events. Statistical analysis will account for the paired nature of the data. DISCUSSION: The findings reinforce that the management of acne vulgaris during the pregnancy–postpartum period remains challenging due to therapeutic limitations and the scarcity of high-quality evidence. The predominance of topical treatments highlights the priority given to maternal and fetal safety, while the treatment of scarring sequelae emphasizes the importance of a comprehensive approach addressing both aesthetic and psychosocial aspects. Despite the increasing use of regenerative procedures, such as microneedling and plasma jet therapy, comparative studies with greater methodological rigor are still needed to establish their efficacy and clinical applicability. CONCLUSION: Acne vulgaris in women's health should be addressed comprehensively, considering both the safe treatment of active disease and its scarring sequelae. Despite therapeutic advances, important scientific gaps remain, reinforcing the need for studies with greater methodological rigor to improve clinical management.

COMMITTEE MEMBERS:
Presidente - 1892581 - GRASIELA NASCIMENTO CORREIA
Interna - 2786809 - MARIA THEREZA ALBUQUERQUE BARBOSA CABRAL MICUSSI
Externa à Instituição - PALLOMA RODRIGUES DE ANDRADE