EFFECT OF TRANSCRANIAL DIRECT CURRENT ELECTROSTIMULATION IN WOMEN WITH PRIMARY DYSMENORRHEA
Primary Dysmenorrhea; Premenstrual Syndrome; Transcranial Direct
Current Stimulation; Pelvic Physical Therapy; Women’s Health.
This doctoral thesis, presented in two studies, aimed to deepen the
investigation into the efficacy of self-administered, home-based transcranial
direct current stimulation (tDCS) as a non-invasive, safe, and accessible
therapeutic alternative for women affected by primary dysmenorrhea (PD)
and premenstrual syndrome (PMS). The research, in general, is based on the
understanding that these gynecological conditions have high prevalence and
are associated with significant negative impacts on pain, mood,
functionality, and quality of life. Furthermore, it is acknowledged that the
prolonged use of pharmacological therapies often leads to adverse effects,
reinforcing the need for new therapeutic approaches. The first study consisted
of a randomized, double-blind, placebo-controlled clinical trial in which
women with PD and PMS used tDCS for five consecutive days during the
menstrual phase of the cycle. The results revealed a clinically significant
reduction in pain intensity in the active group, with the effect maintained in
the following cycle, along with improvements in the psychological domain of
quality of life and emotional symptoms. The intervention proved to be safe,
with no reports of serious adverse events, and showed good adherence among
participants. A critical analysis of the findings suggests that a reduced number
of sessions may be insufficient to promote broader and more sustained
changes. Therefore, the development of a second study with a greater number
of sessions is proposed. In this context, the second study of this thesis aimed to
design a 20-day clinical trial protocol to deepen the understanding of the
effects of neuromodulation, with an emphasis on clinical and
electrophysiological analyses of outcomes, especially those related to
persistent pain, mood, and functionality. Finally, as a scientific contribution,
it is believed that the two articles resulting from this thesis have a positive
impact on strengthening the field of pelvic physical therapy. The results
provide both theoretical and practical foundations for the use of tDCS in
managing menstrual symptoms, in addition to expanding the possibilities for
evidence-based physiotherapeutic interventions in women's health.