Banca de DEFESA: ADRIANA GUEDES CARLOS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : ADRIANA GUEDES CARLOS
DATE: 09/12/2024
TIME: 09:00
LOCAL: Presencial
TITLE:

Bone mineral density and body composition in individuals with and without type 2 Diabetes Mellitus

KEY WORDS:

X-ray photodensitometry, Body Composition, Aging, Bone Mineral Density.

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Introduction: Diabetes Mellitus (DM) is considered a public health problem. It is estimated that 90 to 95% of DM cases are type 2, with a greater presence in developing countries. Type 2 Diabetes Mellitus (DM2) evolved from rapid cultural, economic and social changes. Many people with T2DM are obese or overweight. The increase in physical inactivity and the number of illnesses results in a substantial loss of bone mineral density, while body fat is preserved or increased. With the global obesity epidemic, low bone mineral density and an increase in DM are expected in the coming years. In this context, the measurement of variables and their study are essential in the management of these disorders, in addition to interventions aimed at achieving adequate bone mineral density, which can help control DM2. Objective: To evaluate the discriminative validity and diagnostic accuracy of gynoid fat (%) using Dual-energy X-ray absorptiometry (DEXA) in body composition among women with and without DM2; and evaluate individuals with and without DM2 in relation to bone mineral density and sociodemographic, clinical, functional and laboratory variables. Methodologies: Manuscript 1 - 130 women were evaluated, this is a methodological study of discriminative validity and diagnostic accuracy of Body Composition in gynoid fat (%) evaluated through DEXA, the Consensus-based Standards for the Selection of Health Measurement Instruments ( COSMIN) and the Standards for Reporting Diagnostic Accuracy Studies (STARD). Regarding statistical analyses, the variables were compared between the groups with and without DM2 using the Chi-square or Fisher's Exact test and the T-Student or Mann-Whitney test. The analysis of proportions of a sample (group with DM2) was performed using the Binomial test. The effect size was calculated using the rank-biserial correlation coefficient (r). For diagnostic accuracy, the ROC curve was performed and positive and negative predictive values were calculated. Manuscript 2 - a total of 168 individuals of both sexes were evaluated, Bone Mineral Density (BMD) was measured using DEXA, the study was characterized as analytical observational with a cross-sectional nature. The unpaired t and Mann-Whitney tests were applied. The effect size used for the unpaired t test was Cohen's d, while the effect size calculated for the Mann-Whitney test was the rank-biserial correlation coefficient. To evaluate the association between the dependent variable and the categorical variables, it was the chi-square test or Fisher's exact test was used. The calculated effect size was Cramer's Phi and V coefficient. In both manuscripts, the individuals evaluated were aged at least 40 and at most 85 years old, with and without a diagnosis of DM2. The instruments applied were: clinical characterization questionnaire, cognition (Mini-Mental State Exam); level of physical activity (International Physical Activity Questionnaire); and handgrip strength (dynamometer). Conclusion: Manuscript 1 - The group of women with DM2 had a lower percentage of gynoid fat, the cut-off point found to classify women with DM2 based on gynoid fat was ≤ 47.90 (%); Gynoid fat showed good sensitivity (81.67%), however, low specificity (47.14%), with occasional false positive rates; Recommended for tracking individuals with DM2, with moderate accuracy. Manuscript 2 - There is an association between increasing age and low BMD and complaints of pain in the lower limbs are associated with normal BMD. It was not possible to conclude that the diagnosis of DM2 is a risk factor for having low BMD.

COMMITTEE MEMBERS:
Externo ao Programa - 2442045 - ANDRE GUSTAVO PIRES DE SOUSA - nullExterna ao Programa - 2212172 - CATHARINNE ANGELICA CARVALHO DE FARIAS - nullPresidente - 2090691 - JULIANA MARIA GAZZOLA
Externa à Instituição - SABRINA GABRIELLE GOMES FERNANDES MACEDO - UFRN
Externa à Instituição - VANESSA DA NÓBREGA DIAS