Banca de QUALIFICAÇÃO: DIOGO NERES AIRES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : DIOGO NERES AIRES
DATE: 29/11/2024
TIME: 14:30
LOCAL: Remoto
TITLE:

PROJECT revELA: MONITORING MOTOR SYMPTOMS IN INDIVIDUALS DIAGNOSED OF AMYOTROPHIC LATERAL SCLEROSIS: A LONGITUDINAL STUDY

KEY WORDS:

Amyotrophic Lateral Sclerosis; Motor neurons; longitudinal study

PAGES: 65
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative,
progressive disease that leads to death. The degeneration occurs in motor
neurons located in the cerebral cortex and spinal cord, leading to muscle weakness and atrophy. Due to the heterogeneity of the disease, its clinical
presentation is varied, being classified as spinal ALS, when there is greater
involvement of the limbs; bulbar ALS, when the onset of symptoms begins
with bulbar symptoms; and mixed ALS, when the initial presentation involves
both types. Objectives: To observe the evolution of motor symptoms over a
one-year period in individuals with a definitive or suspected diagnosis of ALS.
Methodology: This is a longitudinal, analytical, and prospective study.
Participants recruited must have a definitive or suspected diagnosis of ALS, of
both sexes, over 18 years old, and be followed by a reference hospital for the
treatment of ALS patients. The instruments applied were ALSFRS-r (Revised
Amyotrophic Lateral Sclerosis Functional Rating Scale) to assess
functionality; VAS (Visual Analog Scale) to assess pain; ALS-CBS (Cognitive
Behavioral Screen) to assess cognition; FSS (Fatigue Severity Scale) to
assess fatigue; in addition to a specific evaluation form containing clinical and
sociodemographic data. The assessment tools were applied either in person
or remotely, every three months, totaling five assessments. Data analysis will
be performed using the Statistical Package for Social Sciences (SPSS)
software version 20.0. A mixed linear model (GLM) will be used to compare
the five assessment moments of the participants. Multiple linear regression
analysis will be used to identify the influence of variables on functionality.
Partial results: The sample consisted of 72 participants, 42 males and 30
females. The average age of the participants was 57 years. 66% of the
individuals had a confirmed diagnosis of ALS, with 54% being spinal type,
12% bulbar type, and 33% classified as mixed. Conclusion: It is expected
that, due to the severity and progression of the disease, individuals diagnosed
with ALS will experience a negative impact on motor symptoms measured by
functionality over the one-year period.

COMMITTEE MEMBERS:
Externa à Instituição - LEDYCNARF JANUÁRIO DE HOLANDA
Externo ao Programa - 3431050 - STEPHANO TOMAZ DA SILVA - nullPresidente - 2319151 - TATIANA SOUZA RIBEIRO