Banca de QUALIFICAÇÃO: ILSA PRISCILA SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ILSA PRISCILA SANTOS
DATE: 06/12/2024
TIME: 09:00
LOCAL: Presencial
TITLE:

Multiparametric Analysis of Nasal Inspiratory Pressure (SNIP) in
Duchenne Muscular Dystrophy: A Case-Control Study with Healthy
Subjects

KEY WORDS:

Neuromuscular Diseases, Duchenne Muscular Dystrophy, Respiratory
muscles, Respiratory Function Tests, Maximal Respiratory Pressure,
Muscle Weakness.

PAGES: 35
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Background: Individuals with Duchenne Muscular Dystrophy (DMD) have
respiratory muscles changes that lead to fatigue and weakness. Assessment
of relaxation rates and contractile properties of inspiratory muscles has been
described as an adjunct measure to identify early respiratory muscle fatigue in
different populations. Aim: To assess the relaxation and contractile rates of
inspiratory muscles non-invasively by measurement of sniff nasal inspiratory
pressure (SNIP) in individuals with DMD and compare them with matched
healthy subjects. Methods: Case-control study with DMD subjects and
healthy controls. We assessed spirometry, maximal respiratory pressures and
SNIP in all subjects. From the SNIP curve we calculated the maximum
relaxation rate (MRR), the constant decay curve (τ, tau) and the maximum
rate of pressure development (MRPD). Results: We studied 32 individuals with DMD and compared them with 32 age-matched and male healthy subjects(12.7 ± 5.1 years). Individuals with DMD had lower lung function and
respiratory muscle strength compared to healthy subjects (p < 0.001). Also,
the DMD group had a significantly lower MRR (5.9 [5.1- 6.9] vs. 8 [6.9- 10.3]
%/ms, p = 0.001) and MRPD (-0.38 [-0.47 to -0.26] vs. -0,62[-0,52 to -0,80]
cmH2O/ms− 1, p = 0.001), in addiction a higher τ (65.7 [50.7-78.1] vs 40.5 [30.2-48.7] ms, p = 0.001). Moreover, ROC curves demonstrated that the parameters derived from the SNIP curve effectively distinguished between individuals with DMD and healthy subjects [SNIP (AUC 0.94 p < 0.001), MRR (AUC 0.86 p < 0.001), τ (AUC 0.92 p < 0.001) and MRPD (AUC 0.89 p< 0.001)]. Conclusions: The contractile properties and relaxation rates of the inspiratory muscles are impaired in individuals with DMD, indicating an early onset of muscle weakness or fatigue. Furthermore, parameters derived from the SNIP curve can effectively differentiate between individuals with DMD and healthy subjects, aiding in the early detection of these changes in clinical practice.

COMMITTEE MEMBERS:
Interno - 1545315 - GUILHERME AUGUSTO DE FREITAS FREGONEZI
Externa à Instituição - LAYANA MARQUES DE OLIVEIRA
Presidente - 5566309 - VANESSA REGIANE RESQUETI FREGONEZI