Banca de DEFESA: MATHEUS LUCENA GERMANO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : MATHEUS LUCENA GERMANO
DATE: 09/10/2024
TIME: 08:30
LOCAL: remoto
TITLE:

ALLOSTATIC LOAD AND PHYSICAL PERFORMANCE IN ELDERLY INDIVIDUALS: RESULTS FROM THE INTERNATIONAL MOBILITY IN AGING STUDY (IMIAS)

KEY WORDS:

Allostatic Load; Physical Performance; Elderly

PAGES: 65
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

ABSTRACT

INTRODUCTION: Allostatic Load (AL) reflects the cumulative impact of chronic stress on the body and serves as an important indicator of physiological adaptation to adversities throughout life. In the elderly, AL is associated with poorer physical performance, greater vulnerability to chronic conditions, cognitive deficits, and depressive symptoms, directly influencing the quality of life and functional health of this population.

OBJECTIVE: To evaluate the association between Allostatic Load (AL) and physical performance scores in elderly individuals from four locations of the International Mobility in Aging Study (IMIAS).

METHODS: This thesis comprises a cross-sectional study with data from 1,101 volunteers from three countries (Canada, Brazil, and Colombia). Three multiple linear regression models were adjusted for age, socioeconomic status (SES), chronic conditions, depressive symptoms, and cognitive function to estimate the independent association between the AL index and the Short Physical Performance Battery (SPPB) scores. Subsequently, a mediation analysis was conducted to examine the total, direct, and indirect effects of AL on SPPB scores.

RESULTS: AL was inversely associated with physical performance, with older adults showing higher AL exhibiting poorer SPPB scores (β: -0.234 Std: 0.033 p-value: <0.001). Indirect effects were observed between age, SES, and chronic conditions with AL and SPPB scores, while chronic conditions showed a total effect on SPPB scores mediated by AL. No significant indirect effects of depressive symptoms and cognitive function on SPPB scores were identified.

CONCLUSION: The study demonstrated that increased levels of AL are associated with poorer physical performance in the elderly. AL plays a mediating role between chronic conditions, depressive symptoms, cognitive state, and physical performance, with socioeconomic status also influencing this relationship.

COMMITTEE MEMBERS:
Externa ao Programa - 1195933 - ANA CAROLINA PATRICIO DE ALBUQUERQUE SOUSA - nullExterno à Instituição - CRISTIANO DOS SANTOS GOMES - UEPE
Externa à Instituição - JULIANA FERNANDES DE SOUZA BARBOSA - UFPE
Presidente - 350637 - RICARDO OLIVEIRA GUERRA
Externa à Instituição - SABRINA GABRIELLE GOMES FERNANDES MACEDO - UFRN