Banca de QUALIFICAÇÃO: PEDRO IVO RAIMUNDO DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : PEDRO IVO RAIMUNDO DA SILVA
DATE: 16/03/2026
TIME: 16:00
LOCAL: Sala de Aulas I GEP/MEJC
TITLE:

HPV Self-Sampling versus Physician Collection and Cytology for Cervical Cancer Screening: Systematic Review and Meta-Analysis.

KEY WORDS:

Self-sampling, Cervical cytology, HPV DNA Tests, Uterine Cervical Neoplasms.

PAGES: 31
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Background: Cervical cancer remains a leading cause of female mortality globally. Despite the effectiveness of Pap smears, low adherence due to healthcare barriers and stigma limits screening coverage. Self-sampled HPV DNA testing has emerged as a promising alternative to increase accessibility, yet its diagnostic accuracy compared to traditional clinician-led methods requires further evaluation to support its implementation in public health programs. Objective: This systematic review and meta-analysis aimed to compare the diagnostic performance of self-sampled HPV DNA testing with traditional cervical cytology and physician-collected HPV DNA testing for cervical cancer screening. Search strategy: A comprehensive search was conducted in PubMed/MEDLINE, Web of Science, Embase, Scopus, CINAHL, and LILACS from inception through March 21, 2024. Selection criteria: We included cross-sectional studies evaluating and comparing the sensitivity and specificity of HPV self-sampling performed by women aged 25 to 65 years against other cervical screening tools (e.g., cervical cytology, physician-collected HPV tests). Data collection and analysis: Study selection and data extraction were performed independently by two reviewers using the Rayyan platform. Risk of bias was evaluated using the QUADAS-2 tool. Pooled estimates for sensitivity and specificity were calculated to assess diagnostic performance. Main results: Forty-nine studies met the inclusion criteria, encompassing a total of 77,057 participants. For the detection of Cervical Intraepithelial Neoplasia 2 or worse (CIN2+), pooled sensitivity estimates were highest for physician-collected HPV testing (0.91; 95% CI: 0.88–0.95), followed by self- sampling HPV testing (0.86; 95% CI: 0.80–0.92) and cytology (0.75; 95% CI: 0.69–0.80). In contrast, pooled specificity was highest for cytology (0.91; 95% CI: 0.87–0.93), surpassing both physician-collected (0.55; 95% CI: 0.42–0.67) and self-sampled HPV testing (0.59; 95% CI: 0.48–0.68). Conclusions: Self-sampling for HPV DNA testing exhibits strong diagnostic performance and represents a promising strategy for cervical cancer screening. While cytology maintains superior specificity, integrating self- sampling into screening programs could improve accessibility, coverage, and equity in underserved populations. Prospero Registration: CRD42023429459; registered on June 04, 2023.

COMMITTEE MEMBERS:
Presidente - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Externo à Instituição - ANTONIO CARLOS QUEIROZ DE AQUINO - ISD
Externa ao Programa - ***.426.804-** - CIJARA LEONICE DE FREITAS - UFRN