Banca de QUALIFICAÇÃO: JANAINA CAVALCANTI COSTA DE OLIVEIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : JANAINA CAVALCANTI COSTA DE OLIVEIRA
DATE: 13/08/2025
TIME: 14:00
LOCAL: Salas da GEP
TITLE:

IMPACT OF NUTRITIONAL THERAPY WITH HUMAN MILK PASTEURIZED COLOSTRUM/HYPERCALORIC ON GROWTH OUTCOMES AND GASTROINTESTINAL COMPLICATIONS IN LOW- AND VERY LOW-BIRTH WEIGHT PREMATURE INFANTS: A RANDOMIZED CONTROLLED TRIAL

KEY WORDS:

Breast milk, Human milk banks, Postnatal growth, Premature newborn

PAGES: 40
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Human milk is widely recommended as the main source of nutrition for preterm newborns, including those with low birth weight (LBW preterm infants), as it contains nutrients and bioactive compounds that support growth and development, in addition to reducing the risk of common clinical complications in this population. Despite the increasing use of colostrum as early oropharyngeal exposure and the artificial fortification of human milk to increase its nutritional density, evidence on the impact of nutritional therapy with adjusted donor human milk on the nutritional outcomes of these newborns remains limited. Thus, this study evaluated two main aspects: (1) the effects of an exclusive human milk diet compared to the introduction of bovine protein-based additives or infant formulas on gastrointestinal complications, analyzed through a systematic review; and (2) the effect of a diet using donor human milk (colostrum + high-calorie milk) compared to the standard diet on the growth of LBW preterm infants admitted to the neonatal intensive care unit (NICU), through a randomized controlled clinical trial (RCT). The systematic review protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and was conducted based on research question: What is the impact of exclusive human milk diet (maternal and donor milk) on the development of gastrointestinal complications in very low birth weight preterm newborns? The review of the articles has not yet begun, and the protocol was registered in PROSPERO (CRD420251056373). To date, the RCT has analyzed data from 33 LBW preterm infants selected within 96 hours after birth or 48 hours after the start of enteral feeding. Participants were randomized into two groups: control (pasteurized mature/transition donor human milk + maternal milk) and intervention (colostrum up to 100 mL/kg/day followed by high-calorie milk + maternal milk). The interventions were maintained until NICU discharge or a change in diet prescription, and weight and length measurements were collected every seven days. The primary outcome was growth, assessed by the velocity of weight gain for age (Z-score). Among the included newborns, the mean gestational age was 31.0 (2.5) weeks, and the mean birth weight was 1,314 (308) g, with 28% of cases presenting intrauterine growth restriction. The average time to regain birth weight was 8.6 (2.6) days. After 14 days, the average length was 41.1 cm (Z = –0.81), and the average weight was 1,554.5 g (Z = –0.80). The partial results suggest an apparent improvement in growth and maintenance of anthropometric adequacy during hospitalization. It is expected that upon completion of the review and the RCT, we will obtain information on whether exclusive and adjusted nutritional therapy with human milk contributes to better growth outcomes and a lower occurrence of gastrointestinal complications.

COMMITTEE MEMBERS:
Interna - 838.782.974-91 - ANNA CHRISTINA DO NASCIMENTO GRANJEIRO BARRETO
Presidente - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES
Externo à Instituição - KLEYTON SANTOS DE MEDEIROS - LNRCC