Banca de QUALIFICAÇÃO: SAHRA MEDEIROS DE MORAIS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : SAHRA MEDEIROS DE MORAIS
DATE: 03/02/2026
TIME: 14:00
LOCAL: Googe meet
TITLE:

HYDROGELS FUNCTIONALIZED WITH ANTIBIOTICS: AMOXICILLIN, CEPHALEXIN, DOXYCYCLINE AND SULFAMETHOXAZOLE + TRIMETHOPRIM FOR TOPICAL USE

KEY WORDS:

Controlled release, Hydrogels, Antimicrobial activity.

PAGES: 63
BIG AREA: Engenharias
AREA: Engenharia de Materiais e Metalúrgica
SUMMARY:

Hydrogels are presented as a controlled-release system for antibiotics, enabling dose reduction and bacterial resistance reduction, as well as reducing systemic adverse effects. Thus, the objective was to develop and characterize polyvinyl alcohol and chitosan-based biopolymers functionalized with antibiotics for controlled release. The hydrogel was synthesized by mixing PVA (15%) and chitosan (2.5%) solutions, with subsequent incorporation of antibiotics into separate hydrogels (amoxicillin, cephalexin, doxycycline, and sulfamethoxazole + trimethoprim). Each drug, at a mass of 125 mg, was diluted in 5 mL of distilled water and homogenized with 10 g of hydrogel base for one hour in a magnetic stirrer, and then in an ultrasonic bath for 30 minutes. The samples were characterized by FTIR, SEM, XRD, and swelling test. The hydrogels were then subjected to in vitro antimicrobial activity testing using tube and plate dilution techniques against Staphylococcus aureus and Escherichia coli bacteria. SEM tests confirmed that the presence of antibiotics contributed to the formation of porous structures. This can be explained by the molecular interaction between the chemical groups of the hydrogel and the antibiotics, with main peaks observed at 3292 cm⁻¹, 2939 cm⁻¹, 1720 cm⁻¹, 1560 cm⁻¹, 1375 cm⁻¹, and 1080 cm⁻¹. Furthermore, XRD testing reinforces this with alterations in the amorphous peak at 20°, which is explained by the reticular interaction through hydrogen bonds between the hydrogel components. The swelling test revealed that the hydrogels absorbed 166% to 514% more than their initial weight. The antimicrobial activity test proved effective, with no turbidity observed in the tube test and no halo formation, being for S. aureus (Amoxicillin - 29 mm; Cephalexin – 32 mm) and for E. coli (Sulfa+tripetropin – 24 mm). After evaluating all the physicochemical and biological behavior of the material, we can conclude that it was possible to develop the biopolymer with efficiency and stability against bacteria.

COMMITTEE MEMBERS:
Presidente - 1458261 - DANY GERALDO KRAMER CAVALCANTI E SILVA
Interno - 2239386 - JOSE IVAN DE MEDEIROS
Externa à Instituição - EDILANE RODRIGUES DANTAS DE ARAÚJO - UFCG
Externa à Instituição - NATHALIE DE SENA PEREIRA - UNINASSAU