Banca de DEFESA: PATRÍCIA GUERRA PEIXE

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : PATRÍCIA GUERRA PEIXE
DATE: 28/02/2020
TIME: 09:00
LOCAL: AUDITÓRIO DO DEPARTAMENTO DE ODONTOLOGIA
TITLE:

The Effect of Aging on the Immunoexpression of CD1a, CD83, Tryptase and CD34 on Healthy and Diseased Periodontal Tissues

KEY WORDS:

Periodontal Disease. Tryptase. CD1a. CD83. CD34. Aging.

PAGES: 56
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

The elderly's microbiota and immune system show some changes, favoring the onset of infections and inflammatory diseases. Periodontal disease is an example, permeating between acute and chronic aspects, it can have changes in its evolution with human aging. Understanding periodontal disease and its relationship with the life cycle is important for prevention, treatment and cure. This study aims to evaluate the effect of aging on periodontal disease, by assessing the presence of immature (CD1a) and mature (CD83) dendritic cells, mast cells (tryptase) and blood vessels (CD34) in 154 healthy and deseased periodontal tissues. The immunohistochemistry technique was used through the immunostaining of CD1a, CD83, tryptase and CD34 markers, being counted in 5 fields with a greater number of positive cells, in the 100x magnification. For CD34, the microvascular area and perimeter were also calculated for all blood vessels present, and for vessels with the presence of high vascular endothelium. There was no difference in the immunoexpression of dendritic cells, mast cells and the amount of blood vessels in the gingival tissues, between cases of clinical gingival health, biofilm-induced gingivitis and periodontitis, evaluating the age groups: adults and adults separately. seniors. Immature dendritic cells are more numerous in the elderly with the clinical picture of gingivitis and periodontitis. In biofilm-induced gingivitis, the elderly have a greater number of mast cells in the degranulation process. Adults with biofilm-induced gingivitis have a greater amount of blood vessels than the elderly group. The microvascular area and the microvascular perimeter of the blood vessels with the high vascular endothelium were larger in the elderly in cases of gingivitis. Concluding, in the elderly with biofilm-induced gingivitis, there is a change in the number of immature dendritic cells, in addition to a change in the caliber of blood vessels with high vascular vessels, requiring studies that relate these data to the cellular function to understand the role of inflammatory cells in periodontal disease.

BANKING MEMBERS:
Externa à Instituição - SABRINA GARCIA DE AQUINO - UFPB
Externa ao Programa - 2085732 - ANA RAFAELA LUZ DE AQUINO MARTINS
Presidente - 1660087 - BRUNO CESAR DE VASCONCELOS GURGEL
Externo à Instituição - FERNANDO JOSE DE OLIVEIRA NOBREGA - UERN
Interna - 350484 - ROSEANA DE ALMEIDA FREITAS