Banca de DEFESA: RAQUEL LÚCIA SOUTO DE ARAÚJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RAQUEL LÚCIA SOUTO DE ARAÚJO
DATE: 28/09/2023
TIME: 10:00
LOCAL: INSTITUTO DO CEREBRO - AUDITÓRIO
TITLE:

Characterization of the role of cortical PKA in the formation of object recognition memory

KEY WORDS:

Protein kinase A, medial prefrontal cortex, object recognition memory

PAGES: 38
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUMMARY:

Recognition memory is a central component of declarative memories. Failures in the processing of these memories lead to severe consequences that characterize the initial symptoms in patients with Alzheimer's and cognitive decline. The novel object recognition task is used to assess the molecular mechanisms involved in recognition memory processing. Different regions of the brain are needed to discriminate objects. The medial prefrontal cortex (mPFC) and the hippocampus perform distinct functions during the processing of this type of memory. Dopamine is important for novelty detection and its signaling is mediated by the cAMP-activated protein kinase, PKA. Disruptions in PKA-mediated signaling can lead to disorders such as attention deficit hyperactivity disorder and age-related memory loss, so to devise more efficient therapeutic strategies, we must understand the neural circuits underlying normal cognition. The objective of this work was to characterize the role of cortical PKA in the formation of object recognition memory in rats. Adult and middle-aged male and female Wistar rats, bilaterally implanted with cannulas in the mPFC, were used. Our results demonstrate that, in rats, consolidation of object recognition memory requires early activation of PKA in the mPFC, this result is observed in both adult and middle-aged males and females. PKA inhibition prevents the formation of long- and short-term object recognition memory. With these findings, we can infer that PKA in the mPFC is fundamental for the formation of object recognition memories.

COMMITTEE MEMBERS:
Interno - 2069422 - DIEGO ANDRES LAPLAGNE
Externa à Instituição - MARIA CAROLINA GONZALEZ - IIN-ELS
Presidente - 1996111 - MARTIN PABLO CAMMAROTA