Banca de QUALIFICAÇÃO: SUZYANNE XAVIER MACIEL

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : SUZYANNE XAVIER MACIEL
DATA : 03/07/2017
HORA: 09:00
LOCAL: INSTITUTO DO CEREBRO
TÍTULO:

Study of spontaneous cortical oscillatory patterns in rats model of autism

PALAVRAS-CHAVES:

autism, valproic acid, neuronal oscillations, somatosensory cortex

PÁGINAS: 92
GRANDE ÁREA: Ciências Biológicas
ÁREA: Fisiologia
RESUMO:

Interacting with the environment and social behavior depend upon the appropriate processing of sensory information from vision, hearing, touch, olfaction and gustation. However, developmental disorders can produce dysfunctions in sensory processing circuits impairing perception and preventing the integration of sensory inputs into interoceptive and emotional circuits. In autism, for instance, abnormal tactile processing is postulated to significantly contribute to the sensory hypersensitivity in patients. Therefore, the aim of our study was to investigate the spontaneous oscillatory activity in the somatosensory cortex of a rodent model of autism by prenatal exposure to valproic acid (VPA) and compare it to controls. Experimental (n=04) and control (n=04) groups were generated by systemic administration of VPA (500 mg/Kg) or saline in E12 pregnant rats, respectively. By adulthood, the animals were anesthetized with urethane and local field potentials were recorded in the left somatosensory cortex using a 4x4 electrode array. We analyzed the occurrence and features of discrete oscillatory events (e.g. spindle-bursts, slow waves) as well as the occurrence and characteristics of epileptiform activity in control and experimental animals.

MEMBROS DA BANCA:
Interno - 1674643 - MARCOS ROMUALDO COSTA
Presidente - 1698305 - RODRIGO NEVES ROMCY PEREIRA
Interno - 1939184 - SANDRO JOSE DE SOUZA