Banca de DEFESA: ARTHUR SERGIO CAVALCANTI DE FRANCA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : ARTHUR SERGIO CAVALCANTI DE FRANCA
DATA : 04/11/2016
HORA: 08:30
LOCAL: INSTITUTO DO CÉREBRO
TÍTULO:

The role of beta2 oscillations and OLMα2 interneurons in the CA1 region of the mouse hippocampus in object recognition memory

PALAVRAS-CHAVES:

Hippocampus; CA1; OLMα2; Memory; Object Recognition

PÁGINAS: 130
GRANDE ÁREA: Ciências Biológicas
ÁREA: Fisiologia
RESUMO:

The hippocampus is associated to novelty detection and formation of explicit memories. The present work aims at better understanding the role of the CA1 region of the hippocampus in these processes. By employing electrophysiology, animal behavior, psychopharmacology and optogenetic techniques in transgenic and wild-type mice, we found that CA1 OLMα2 cells influence the formation of new object representations in an object recognition task, as well as the encoding of aversive memories in a contextual fear memory task. Furthermore, we characterized a new oscillatory activity in the local field potential of CA1 at beta 2 frequency (23-30 Hz), which was typically transient and linked to the amount of novelty in an object recognition task. These results suggest potential cellular and network mechanisms that underlie the role of CA1 in memory formation and novelty detection.

MEMBROS DA BANCA:
Presidente - 1721223 - ADRIANO BRETANHA LOPES TORT
Externo à Instituição - CLAUDIO DA CUNHA - UFPR
Interno - 2069422 - DIEGO ANDRES LAPLAGNE
Externo à Instituição - FLAVIO FREITAS BARBOSA - UFPB
Externo ao Programa - 2326928 - JANINE INEZ ROSSATO