Banca de QUALIFICAÇÃO: RAFAEL DOS SANTOS DE BESSA
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.DISCENTE : RAFAEL DOS SANTOS DE BESSA
DATA : 27/07/2016
HORA: 14:00
LOCAL: INSTITUTO DO CÉREBRO
TÍTULO:
CORTICOHIPPOCAMPAL ELECTROPHYSIOLOGICAL ACTIVITY ANALYSIS DURING THE STATUS EPILEPTICUS AND THE "SILENT" PERIOD IN EPILEPSY ANIMAL MODELS INDUCED BY INTRA-HIPPOCAMPAL PILOCARPINE AND KAINIC ACID
PALAVRAS-CHAVES:
Temporal Lobe Epilepsy, Status Epilepticus, Pilocarpine, Kainic Acid, Electrophysiology, Hippocampus, prefrontal Cortex.
PÁGINAS: 45
GRANDE ÁREA: Ciências Biológicas
ÁREA: Fisiologia
RESUMO:
Temporal lobe epilepsy (TLE) is the most common type of epilepsy in adults and one with the highest incidence of psychiatric comorbidities. It is commonly associated with early brain insults that can lead to disfunctions in mesial temporal regions such as the amygdala, hippocampal formation and enthorhinal cortex (Engel, 2001). Understanding the mechanisms of ictiogenesis and epileptogenesis has been significantly expanded due to studies in animal models. Among the most used models of TLE are those that reproduce epileptic features in animals by the induction of a long-lasting convulsant state, called status epilepticus (SE). They use systemic administration of chemical convulsants such as kainic acid and pilocarpine (BenAri & Lagowska, 1979; Turski et al., 1983). However, problems commonly shown by these models involve a great variability in behavioral expression and cellular damage. Possible causes of these effects are (1) the systemic drug administration, (2) the insufficient SE blockade and (3) the absence of electrophysiological monitoring during the SE and subsequent days as a way to control the animals’ response variability. Therefore, our study aimed to compare the pilocarpine and kainic acid models of TLE using the following methodological modifications: intrahippocampal drug injection, the use of a more potent anticonvulsant cocktail (ACC) and the use of electrophysiological monitoring during the SE. We also investigated the early stages of epileptogenesis during the first days (3d) postSE, in order to characterize the socalled “silent” period that precedes the emergence of spontaneous recurrent seizures (SRS).
MEMBROS DA BANCA:
Interno - 1728817 - CLAUDIO MARCOS TEIXEIRA DE QUEIROZ
Interno - 2069422 - DIEGO ANDRES LAPLAGNE
Interno - 1976236 - EMELIE KATARINA SVAHN LEAO
Presidente - 1698305 - RODRIGO NEVES ROMCY PEREIRA