Banca de QUALIFICAÇÃO: KARIELY GONÇALVES DE MOURA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : KARIELY GONÇALVES DE MOURA
DATE: 30/07/2021
TIME: 14:00
LOCAL: Remoto
TITLE:

EVALUATION OF THE BEHAVIORAL EFFECTS OF SHORT AND LONG-TERM SUCROSE WITHDRAWAL IN FEMALE RATS

KEY WORDS:

Sucrose withdrawal, anxiety, elevated plus maze, open field, female rats

PAGES: 68
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUBÁREA: Neuropsicofarmacologia
SUMMARY:

Sugar is a highly flavorful and rewarding substance. Its consumption usually causes sensations, such as an improvement in mood and a decrease in agitation. Physiologically, the ingestion of highly palatable foods increases dopamine in the nucleus accumbens and the decrease in dopamine signaling leads to reduced activity in this region, which can happen in anxiety-related behaviors. The present study tested the hypothesis that sucrose withdrawal after prolonged exposure would favor anxiety-related behaviors in adolescent females. Adolescent rats (30 days), except for the control group, underwent treatment with sucrose at a concentration of 5% free choice for 16 days. After 16 days, sucrose was replaced by water according to two protocols. For the Short-term Withdrawal group, sucrose was replaced by water for 72 hours prior to testing. For the Long-term withdrawal group, sucrose was replaced by water for 21 days. After the withdrawal period, the animals were taken to the elevated plus maze and open field behavioral tests. In the elevated plus maze, the long-term withdrawal group had its exploration time reduced compared to the control and continuous sucrose group. The long-term withdrawal group entered the closed arms more often compared to the control and short-withdrawal groups. In the open field, there was no treatment effect on the three parameters analyzed during the first five minutes of the test: number of entries into the center, time spent in the center and distance covered in the center. In conclusion, long-term sucrose withdrawal produces anxious-like behaviors and increases locomotion in the elevated plus-maze. More studies should be carried out to understand the neural bases involved with anxiety in sucrose withdrawal.

BANKING MEMBERS:
Presidente - 1720860 - VANESSA DE PAULA SOARES RACHETTI
Interno - 2412258 - EDILSON DANTAS DA SILVA JUNIOR
Externa ao Programa - 2121895 - ALIANDA MAIRA CORNELIO DA SILVA