Banca de QUALIFICAÇÃO: ANA CLARA DA COSTA NUNES GOMES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : ANA CLARA DA COSTA NUNES GOMES
DATA : 17/12/2018
HORA: 14:00
LOCAL: Sala de Reuniões do CB
TÍTULO:

Agomelatine in female rats: effects on anxiety-related behaviours in light of its antidepressant effect

PALAVRAS-CHAVES:

Agomelatine, anxiety, depression, elevated plus-maze elevated T-maze, forced swimming test, mTor

PÁGINAS: 70
GRANDE ÁREA: Ciências Biológicas
ÁREA: Farmacologia
RESUMO:

Agomelatine is a MT1 and MT2 receptors agonist and 5-HT2C receptor antagonist used in the pharmacotherapy of depressive disorders. In addition, its use has been suggested to relieve symptoms of anxiety disorders, including panic attacks. The aim of present study was to evaluate if agomelatine administration alters anxiety-related responses in female rats, based on the antidepressant profile already well established in the literature. Wistar rats were submitted to two tests of anxiety based on innate aversion of rats to open and unprotected places, the elevated plus-maze (EPM) and the elevated T-maze (ETM) and to the forced swimming test (FST), that measures coping strategy to an acute inescapable stress and it is a useful tool in the screening for antidepressant drugs. There were no changes in the locomotor activity of the females submitted to the oral administration of agomelatine (25, 50 or 75 mg/Kg) or saline as assessed in the open field test. Regarding anxiety-like responses, the acute administration of agomelatine (12.5, 25 or 50 mg/Kg) did not alter the exploration of the EPM by the females. In the ETM, agomelatine administered sixty minutes before both pre-test and test sessions did not modify the inhibitory avoidance acquisition or escape response at any of the doses tested (25, 50 and 75 mg / kg). In FST, administration of agomelatine (50 mg / kg) did not alter climbing behavior, but reduced immobility time, thus reinforcing in females the antidepressant-like profile of this drug. The pre-frontal cortex of an independent group of rats was collected for Western blot procedure and marking of mTOR protein in order to verify whether this intracellular signaling pathway is altered after administration of agomelatine.

MEMBROS DA BANCA:
Interno - 1720860 - VANESSA DE PAULA SOARES RACHETTI
Externo ao Programa - 1645202 - ELAINE CRISTINA GAVIOLI
Externo ao Programa - 2140860 - ROVENA CLARA GALVAO JANUARIO ENGELBERTH