Banca de DEFESA: JOELMA MARIA DE ARAÚJO ANDRADE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : JOELMA MARIA DE ARAÚJO ANDRADE
DATA : 31/08/2018
HORA: 14:00
LOCAL: sala de aula Pós-Graduação
TÍTULO:

Study of polymorphisms in the IL17A and IL17RA genes and IL-17A, IL-33 and CCL2 production in infected pregnant women with Toxoplasma gondii from the State of Rio Grande do Norte, Brazil.

PALAVRAS-CHAVES:

Toxoplasma gondii, Gene polymorphism, cytokines, IL17, Clinical Manifestations.

PÁGINAS: 72
GRANDE ÁREA: Ciências Biológicas
ÁREA: Parasitologia
SUBÁREA: Protozoologia de Parasitos
ESPECIALIDADE: Protozoologia Parasitária Humana
RESUMO:

Toxoplasmosis is an infectious parasitic disease that triggers Toxoplasma gondii, which can cause tumors when immunocompromised and/or vertically infected, triggering encephalitis, chorioretinitis and neurological and psychiatric disorders. In the present study, we evaluated polymorphisms for IL-17A and IL-17RA genes, as well as IL-17A, IL-33 and CCL2 status of patients with clinical manifestations of toxoplasmosis in the state of Rio Grande do Norte. The non-polymorphic range of the SNP rs2275913, located in the promoter region of its IL17A gene, has shown that the G allele has a protective role in the population of pregnant women, but not in the population with ocular toxoplasmosis. What is polymorphism -809 A> G SNP rs4819554, located without gene by the coding of the IL-17A receptor, IL-17RA, results found in the population of pregnant women, the allele With protective effect of the G allele non-polymorphism IL17A -197 (Rs2275913), but in the population with ocular toxoplasmosis, the presence of two alleles related to increased IL-17A activity is associated with the manifestation of symptoms characteristic of this form of toxoplasmosis. When analyzing the cytokine/chemokine dosages IL-17A, IL-33, and CCL2, it was found that this contributed to the clinical picture of hypertension in women, but not to those who reported the occurrence of abortion. This work, therefore, presents a broader perspective of the immunomodulation promoted by T. gondii, in the population of Rio Grande do Norte.

MEMBROS DA BANCA:
Presidente - 1346635 - JANEUSA TRINDADE DE SOUTO
Externo ao Programa - 1714262 - LILIAN GIOTTO ZAROS DE MEDEIROS
Externo ao Programa - 350753 - VALERIA SORAYA DE FARIAS SALES
Externo à Instituição - MANUELA SALES LIMA NASCIMENTO - IINN