Banca de QUALIFICAÇÃO: JOELMA MARIA DE ARAÚJO ANDRADE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : JOELMA MARIA DE ARAÚJO ANDRADE
DATA : 06/08/2018
HORA: 14:00
LOCAL: sala de aula Pós-Graduação
TÍTULO:

IL17A AND IL17R POLYMORPHISMS AND CCL2, IL-17A AND IL-33 STATUS IN THE PATIENTS WITH DIFFERENT CLINICAL MANIFESTATIONS OF TOXOPLASMOSIS IN THE STATE OF RIO GRANDE DO NORTE, BRAZIL

PALAVRAS-CHAVES:

Toxoplasma gondii, Gene polymorphism, cytokines, IL17, Clinical Manifestations.

PÁGINAS: 72
GRANDE ÁREA: Ciências Biológicas
ÁREA: Parasitologia
SUBÁREA: Protozoologia de Parasitos
ESPECIALIDADE: Protozoologia Parasitária Humana
RESUMO:

Toxoplasmosis is an infectious parasitic disease caused by Toxoplasma gondii, which can have serious consequences when it affects immunocompromised patients and/or vertically infected fetuses, triggering encephalitis, chorioretinitis, and neurological/psychiatric disorders. In this study, we evaluated polymorphisms for the IL17A and IL17R genes, as well as the status of CCL2, IL-17A, and IL-33 from patients with different clinical manifestations of toxoplasmosis in the State of Rio Grande do Norte. The results obtained for IL-17A show SNPs in the promoter region of its IL17A gene, rs2275913-197 G> A, which has been implicated in the production of elevated levels of IL-17A; as well as SNPs rs4819554 (A> G) in the gene responsible for encoding its receptor, IL-17RA. Such polymorphisms associated with CCL2 and IL-33 levels show important repercussions for the individuals evaluated in this study, especially in ocular toxoplasmosis, a fact that was not clearly observed in gestational toxoplasmosis. This work, therefore, opens perspectives for a better knowledge of the immunomodulation promoted by T. gondii, in the population of Rio Grande do Norte.

MEMBROS DA BANCA:
Presidente - 1346635 - JANEUSA TRINDADE DE SOUTO
Interno - 2492944 - CAROLINE ADDISON CARVALHO XAVIER DE MEDEIROS
Externo ao Programa - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS