Banca de DEFESA: KARINA DA SILVA MARANHÃO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : KARINA DA SILVA MARANHÃO
DATE: 17/03/2026
TIME: 08:30
LOCAL: Auditório do PPGBioEF
TITLE:

Assessment of the impact of overweight on the reproductive outcomes of infertile women undergoing in vitro fertilization.

KEY WORDS:

Infertility; Anovulation; BMI; Assisted Reproductive Technology; Embryo Quality; Pregnancy.

PAGES: 52
BIG AREA: Ciências Biológicas
AREA: Morfologia
SUMMARY:

The desire to have a baby is present in the aspirations of a large portion of adults. However, not every
couple can achieve pregnancy spontaneously, and some require assisted reproductive technology (ART)
treatments. Among the causes related to female infertility, alterations in body mass index (BMI) stand out,
associated or not with other factors such as endometriosis and anatomical factors, which can impact
reproductive stages in different ways during ART treatments. In this context, this study aimed to evaluate
the oocyte and embryo quality of patients undergoing in vitro fertilization (IVF) with different degrees of
BMI, associated or not with other infertility factors. To this end, a descriptive, longitudinal, and
retrospective observational study was conducted, based on the collection of secondary data at the
Assisted Reproduction Center of the Januário Cicco Maternity School (Natal – RN), where the medical
records of patients treated between 2013 and 2024 were analyzed. After applying inclusion and exclusion
criteria, 189 patients, who consented to access their medical records, comprised the sample for this study.
BMI proved to be one of the most relevant infertility factors, with 29.51% of patients in this study being
eutrophic and 65.57% overweight. Only 2 patients were underweight and 4 were obese (grade 1). In the
comparative analysis between eutrophic and overweight patients, no statistically significant differences
were observed regarding the oocyte parameters analyzed (p>0.05). However, parameters such as antral
follicle count and the number of oocytes retrieved were significantly reduced when overweight was
associated with other infertility factors, such as endometriosis, advanced age, and tubal factors. Negative
impacts of overweight were also observed when analyzing parameters indicative of both oocyte and
embryo quality. It was also observed that embryos from overweight patients presented a higher
percentage of mild embryonic fragmentation on the third day post-IVF (p<0.05), with no significant
difference when compared to moderate or severe fragmentation. The analysis of oocyte dysmorphisms
showed no statistically significant differences in morphological alterations between eutrophic and
overweight patients, although the overweight group presented a higher average number of ruptured
oocytes and an increased perivitelline space. The results of this study highlight the significant impact of
weight on patients' oocytes, although weight alone does not appear to interfere with the quality of
embryos produced from these oocytes. It is not known, however, whether the impacts identified by this
data could induce genetic alterations in these embryos that could lead to long-term impairments during
gestation or in the postnatal period.

COMMITTEE MEMBERS:
Interna - 1718086 - DANIELLE BARBOSA MORAIS
Externa à Instituição - DÉLIS DE OLIVEIRA FERREIRA
Externa ao Programa - 3291543 - RENATA SWANY SOARES DO NASCIMENTO - null