Banca de DEFESA: LYGIA MARIA COSTA SOARES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LYGIA MARIA COSTA SOARES
DATE: 30/06/2025
TIME: 17:00
LOCAL: Via Google Meet
TITLE:

FACTORS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS VACCINE HESITANCY IN THE BRAZILIAN POPULATION: A CROSS-SECTIONAL STUDY

KEY WORDS:

Vacina contra HPV. Hesitação Vacinal. Câncer cervical.

PAGES: 125
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUBÁREA: Saúde Pública
SUMMARY:

HPV related tumors continue to be a global leading cause of cancer mainly due to cervical cancer (CC) burden. In Brazil, CC is the third most common cancer and the fourth highest cancer mortality rate among women. HPV vaccine mass immunization represents the current most promising intervention for CC prevention. It was first implemented in the Brazilian public health system in 2014, however, despite a history of excellent coverage for other vaccines, HPV vaccine uptake is below the necessary threshold for CC elimination. Identifying the factors that influence HPV vaccine hesitancy is an essential step to further develop strategies to improve vaccination coverage. The aim of this study is to know whether or not Brazilians are resistant to HPV vaccination and to determine the factors and variables that influence this decision. This is a population-based cross-sectional study which used quantitative methodology through personal interviews. A total of 2,010 interviews were planned to result in error margins of 2 percentage points, more or less considering a 95% confidence level, encompassing all five Brazilian regions. The research was carried out with the Brazilian population aged 16 and over, interviewees were approached at points of population flow. Between June 12 th and 16 th 2023, a total of 2,010 personal interviews were done, with participants from all five Brazilian regions. The prevalence of vaccine resistance was 5.97% (95% confidence interval [CI], 4.93–7.23) among those interviewed. A multivariate analysis demonstrated greater resistance to the vaccine among men (prevalence ratios (PR): 1.58; 95%CI, 1.06–2.34; p: 0.023) and residents in the South region of the country (PR: 1.77; 5%CI, 1.06–2.94; p: 0.028). The three main reasons for refusing the vaccine reported by the participants were: lack of knowledge about the HPV vaccine; difficulty in accessing the vaccine; and lack of vaccine prescription by health professionals. Safety was the main reason not to vaccinate, cited by 10 %. Despite HPV vaccine availability in Brazil at the public health system, vaccination coverage remains below the target for both genders. However, according to this analysis, there is a low rate of HPV vaccination hesitancy in the country, being lack of knowledge, difficulty in accessing the vaccine and lack of vaccine prescription by health professionals the main obstacles to adequate adherence. The COVID-19 pandemic doesn’t seem to have affected HPV vaccination resistance in the country. Proper strategies for vaccine implementation, including school-based programs, patient-provider communication and education, and integrated monitoring and evaluation strategies are needed, otherwise, HPV vaccine programs risk repeating problems like other cancer prevention programs in low- and middle-income countries. The HPV vaccine is an efficient tool for preventing cancer, which saves lives, but in Brazil it is being underused.

COMMITTEE MEMBERS:
Presidente - 2262871 - ANA ELZA OLIVEIRA DE MENDONCA
Interna - 2374850 - THAIZA TEIXEIRA XAVIER NOBRE
Externo ao Programa - 2495698 - JOSE DINIZ JUNIOR - UFRNExterna à Instituição - ANGÉLICA RODRIGUES NOGUEIRA - HMS
Externa à Instituição - ANDREIA CRISTINA MELO - INCA
Externo à Instituição - EDUARDO PAULINO - INCA