EXPERIMENTAL ANTIMALARIAL CHEMOTHERAPY WITH DEHYDRATED COCOS NUCIFERA BEE POLLEN EXTRACTS
Malaria, Plasmodium berghei, Cocos nucifera, Bee pollen, Antimalarial drugs
One of the limiting factors for malaria control is the resistance of Plasmodium to the usual antimalarials. The rational search for new compounds derived from natural products with activity against Plasmodium is an excellent approach. Therapeutic substances such as those derived from bee pollen of Cocos nucifera are a possible resource, as the ethnopharmacological power of their chemical substances in herbal medicines is known. Some studies have observed the anti-inflammatory, antioxidant, antibacterial, antiparasitic and anticancer potential of extracts derived from C. nucifera products, correlating these activities with their bioactive compounds. The variety of bioactive substances found in C. nucifera as phenolic compounds is immense, the triterpenes, saponins and tannins are related to antiparasitic activities, therefore the therapeutic potential with the bee pollen of cocos nucifera is potentiated due to the bees add nectar and substances in addition to its known nutritional properties. In this context, the need for investigations into new drugs with antiplasmodial potential is remarkable, therefore, the knowledge of etomopharmacology, and of existing compounds, gives us an understanding of how the drugs used in medicine herbal medicine, can help in the discovery of new substances, both to potentiate existing drugs, with combinatorial therapies and to find new substances.