Neuromuscular and biochemical responses among individuals with chronic obstructive pulmonary disease (COPD) and healthy
COPD; Isokinetic; Muscular Fatigue.
Introduction: Chronic obstructive pulmonary disease (COPD) produces significant systemic consequences, such as skeletal muscle dysfunction, which predisposes to early muscle damage and / or fatigue. These changes may be a major reason for disability in COPD patients, decreasing performance in activities of daily living, work, and health-related quality of life. Objective: To compare neuromuscular and biochemical responses of femoral quadriceps muscle damage and fatigue among COPD and healthy individuals. Methodology: This is an observational, cross-sectional and comparative study. The sample consisted of 18 individuals allocated in two distinct groups: COPD Group (GD) and Healthy Group (GS). They were evaluated through spirometry; Of the neuromuscular performance of the quadriceps; The biochemical markers of muscle damage and fatigue; Fatigue and muscle pain. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 20.0 with significance level of 5%. Results: There was a statistically significant difference in power (p = 0.02) and a tendency to the difference in total work (p = 0.06) between the groups. In the analysis of the biochemical marker, LDH, for muscle fatigue, a significant difference between the groups was observed immediately after the isokinetic test in the quadriceps (p = 0.03). CONCLUSIONS: The neuromuscular, biochemical responses of muscle quadriceps muscle damage and fatigue in COPD are decreased in the study population.