Banca de QUALIFICAÇÃO: JULIA ROBERT DE SOUSA TEIXEIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : JULIA ROBERT DE SOUSA TEIXEIRA
DATE: 05/04/2023
TIME: 09:00
LOCAL: Video conferência
TITLE:

 

 EXPOSIÇÃO AO DIFLUBENZURON NO DESENVOLVIMENTO E COMPORTAMENTO DE ZEBRAFISH (Danio rerio)

KEY WORDS:

embryotoxicity; neurotoxicity; diflubenzuron; larvicide; zebrafish.

PAGES: 18
BIG AREA: Ciências Humanas
AREA: Psicologia
SUMMARY:

The use of pesticides (agrochemicals or agricultural defensives) in order to provide greater productive yield of large harvests by preventing the harmful action of pests and diseases is on the rise. However, despite the indications of toxicological risks and the effectiveness of these products, it is difficult to know the real impacts of acute and chronic exposure from the consumption of water and food previously exposed to these chemical products. In addition to human consumption, animals that live in aquatic environments are directly affected by not only one product, but the mixture of various pesticides used in crops. The consequences of graded exposure are still uncertain and need further investigation. Among the most widely used pesticides, diflubenzuron (DFB) is an insecticide derived from urea and classified as an insect growth regulator (IGR) for preventing the formation of chitin, the main constituent of the exoskeleton of arthropods. Although directed to insects, the conservation of several characteristics of carbohydrates (such as chitin), proteins and lipids throughout evolution, as well as the potential for bioaccumulation of chemical elements in consumer organisms, raise the question of the effects of pesticides on other animal groups besides those directly affected, such as insects. Thus, the biosafety assessment of products such as DFB and other pesticides should be considered using vertebrate animal models. In this sense, the present study aims to evaluate the toxicity of DFB in the embryonic development of zebrafish (Danio rerio), considered a translational model due to the homology of about 70% of the genome with humans, in addition to the experimental benefits offered by the high fecundity and easy maintenance. This work will evaluate the effects of different concentrations of DFB on survival and ontogenetic development, the behavior of reflex, locomotor and cognitive responses, in order to identify the possible toxic effects of exposure to DFB in non-target organisms.

COMMITTEE MEMBERS:
Presidente - 1644341 - ANA CAROLINA LUCHIARI
Externa ao Programa - 2888478 - DENISE MORAIS LOPES GALENO - null