Banca de QUALIFICAÇÃO: MARIANA MAIA DE MEDEIROS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIANA MAIA DE MEDEIROS
DATE: 04/04/2025
TIME: 16:00
LOCAL: Instituto do Cérebro
TITLE:

PSYCHEDELIC DREAMS: AN INVESTIGATION OF THE RELATIONSHIP BETWEEN DMT AND LUCID DREAMS

KEY WORDS:

Lucid dreams; N,N-dimethyltryptamine (DMT); Psychedelics; Consciousness; Altered states of consciousness; REM sleep; Dreams; Nightmares.

PAGES: 28
BIG AREA: Ciências Humanas
AREA: Psicologia
SUBÁREA: Psicologia Experimental
SPECIALTY: Estados Subjetivos e Emoção
SUMMARY:

Introduction: Recent studies have shown similarities between dream states and psychedelic-induced states, particularly with regard to vivid mental imagery, activation of emotions, and attenuation of fear memories. Evidence suggests that these similarities are more pronounced when individuals are aware that they are dreaming, which characterizes lucid dreams (LS). However, to our knowledge, there is no study that has directly investigated the quantitative relationship between psychedelics and frequency of dream recall. Objective: The present study sought to investigate the relationship between inhaled N,N-dimethyltryptamine (DMT) administration and the frequency of LS recall in healthy individuals. Method: Using an open, fixed-dose, escalating design, we assessed changes in LS recall at different time points after DMT administration. On D0, a first lower dose was used, followed by a second higher dose 2 hours later. We applied questionnaires about sleep, dreams, LS and nightmares at four different times: D0 = day of dosing, D1 = one day, D14 = fourteen days and D28 = twenty-eight days later. With the exception of D1, in which the questions referred to the previous night, the other three questionnaires (D0, D14 and D28) referred to the previous two weeks. Results: Our sample consisted of 25 volunteers, including 13 men and 12 women (mean age = 30.28 years and standard deviation = 6.52 years), mostly white, single adults, with completed higher education, employed, without a defined religion, but with spirituality. In a first descriptive analysis, comparing data between D0 and D28, we found that the percentage of LS increased by 23%. Using a generalized linear mixed model with Poisson distribution and logarithmic link for SL count (Wald test), we observed that SL decreased on D14 (p = 0.03) and D28 (p = 0.01) among subjects treated with the lowest dose of DMT (5-20 mg), compared to baseline (D0). In contrast, participants treated with the highest dose (15-60 mg) presented higher SL frequency on D14 (p = 0.003) and D28 (p = 0.006) compared to baseline (D0). Conclusion: These findings suggest a dose-time-dependent relationship between DMT and SL, which may contribute to the understanding of the neurobiological mechanisms underlying sleep-related and psychedelic-related dissociative states of consciousness.

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