Banca de QUALIFICAÇÃO: KARIELY GONÇALVES DE MOURA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : KARIELY GONÇALVES DE MOURA
DATE: 29/11/2024
TIME: 09:30
LOCAL: remota
TITLE:

Excessive Sucrose Consumption Induces Anxiety-like Behaviors and Oxidative Damage in the Frontal Cortex of Middle-aged Mice

KEY WORDS:

Sucrose, Anxiety, Psychiatric disorders, Withdrawal.

PAGES: 69
BIG AREA: Ciências Humanas
AREA: Psicologia
SUMMARY:

Excessive sugar intake has been associated with several metabolic and
cardiovascular disorders. Furthermore, there is a significant relationship between
high sugar consumption and the prevalence of psychiatric disorders in the population.
Thus, the study investigated whether the intake and withdrawal of sugar from the diet
can favor the emergence of behaviors associated with psychiatric disorders in
middle-aged mice, exploring the behavioral, metabolic and neurochemical aspects
involved. For this purpose, male Swiss mice were exposed to sucrose solution for 28
days (free choice) and after a 7-day withdrawal period, they were evaluated in
behavioral and neurochemical tests. The following behavioral tests were used:
elevated plus maze, open field and tail suspension test. For neurochemical
evaluation, after the behavioral evaluation, the animals were euthanized and blood
samples and samples of the frontal cortex, hippocampus and midbrain were
collected. Prolonged sucrose consumption as well as its withdrawal induced greater
anxiety behavior. Animals spent less time in the open arms of the elevated plus
maze. In the open field test, although there was no difference in the distance traveled
between the groups, the animals with continuous exposure to sucrose explored the
center of the arena less. In the tail suspension test, neither prolonged sucrose
consumption nor its withdrawal altered depressive-like behavior. Sucrose exposure
increased oxidative damage in frontal cortex lipids, even after 1 week of withdrawal,
but it did not alter protein carbonylation. No significant changes in oxidative damage
in the hippocampus and midbrain were observed due to sucrose. Finally, our data
suggest that 1-week withdrawal of sucrose attenuates the negative effect on
cholesterol levels, but it was not sufficient for reversing the prolonged sucrose
exposition-induced anxiety-like behaviour and frontal cortex oxidative damage in
mice.

COMMITTEE MEMBERS:
Presidente - 1645202 - ELAINE CRISTINA GAVIOLI
Interna - 2140860 - ROVENA CLARA GALVAO JANUARIO ENGELBERTH
Externo à Instituição - VICTOR ANASTÁCIO DUARTE HOLANDA