Banca de DEFESA: FABIOLA LEITE GOUVEIA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : FABIOLA LEITE GOUVEIA
DATE: 31/08/2026
TIME: 15:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

Flow Cytometric Immunophenotypic Assessment of Polyendocrine Metabolic Ovarian Syndrome: Investigation of Immuno-inflammatory Biomarkers in Patients Treated at the Januário Cicco Maternity Hospital, Natal, RN

KEY WORDS:

Polyendocrine Metabolic Ovarian Syndrome; Flow Cytometry; Inflammation; Biomarkers; T-Lymphocyte Subsets.

PAGES: 107
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Polyendocrine Metabolic Ovarian Syndrome (SOMP) is the primary endocrine gynecological disorder in women of reproductive age, characterized by a chronic low grade inflammatory state associated with metabolic comorbidities. However, gaps remain in understanding how peripheral immune activation markers reflect this inflammatory stress independently of body mass index. This study was justified by the need to identify cellular biomarkers for the immuno-inflammatory monitoring of the syndrome. This case-control clinical study evaluated the immunophenotypic profile and cellular inflammatory indices of 67 obese and non-obese women (39 cases and 28 controls, aged 20–40 years) treated at the Gynecology and Endocrinology outpatient clinic of Maternidade Escola Januário Cicco / UFRN. Peripheral blood samples were analyzed by flow cytometry to evaluate T and B lymphocytes, basal activation markers (CD38+, HLA-DR, perforin, granzyme), and inflammatory indices (NLR, SII, SIRI, AISI), using Student's t-test, Mann-Whitney test, and Spearman's correlation (p < 0.05). The results showed that peripheral adaptive immunity and basal activation markers remained homogeneous between the groups. However, the SOMP group presented a significant reduction in the percentage of CD45+ cells (85.0% vs. 92.5%; p = 0.016) and NK cells (4.0% vs. 8.0%; p = 0.030), accompanied by a higher absolute lymphocyte count (2,59 vs. 2,22 × 109/L; p = 0,018). Cellular inflammatory indices were higher in the control group (NLR: 1.84 vs. 1.50, p = 0.016; SII: 579 vs. 418, p = 0.004). Spearman's analysis revealed exclusive interactions in the SOMP group: CD38+ correlated positively with the SII (ρ = 0.332), SIRI (ρ = 0.477), and AISI (ρ = 0.388) indices, advancing age was associated with NLR (ρ = 0.345; p = 0.032), and systolic blood pressure correlated with SII (ρ = 0.326; p = 0.043). Therefore, it can be concluded that SOMP promotes dysregulation in peripheral innate immunity and inflammatory indices independently of obesity. The model suggests that metabolic alterations direct the peripheral response, validating immunophenotyping as a clinical biomarker and paving the way for adjuvant therapies based on the immunometabolism of the syndrome.

COMMITTEE MEMBERS:
Externa ao Programa - 3075402 - DEYSE DE SOUZA DANTAS - nullExterna à Instituição - ELYS COSTA DE SOUSA - UNI-RN
Interno - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Interna - 1143827 - JULIANA FELIX DA SILVA
Presidente - 1055045 - MARCELA ABBOTT GALVAO URURAHY
Externa à Instituição - MELINA BEZERRA LOUREIRO - UnP
Externa ao Programa - 1306690 - TELMA MARIA ARAUJO MOURA LEMOS - null