Banca de QUALIFICAÇÃO: FABIOLA LEITE GOUVEIA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : FABIOLA LEITE GOUVEIA
DATE: 29/05/2026
TIME: 15:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

Definition of an Immunophenotypic Profile in Polycystic Ovary Syndrome Using Flow Cytometry for the Investigation of Diagnostic Markers

KEY WORDS:

Polycystic Ovary Syndrome; Flow Cytometry; Inflammation; Biomarkers; T-Lymphocyte Subsets.

PAGES: 89
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder with an

estimated prevalence ranging from 9% to 18% in the reproductive-age female

population, establishing itself as the primary hormonal gynecological dysfunction.

Characterized as one of the most frequent endocrine-gynecological disorders, the

syndrome exhibits a close correlation with various metabolic comorbidities, including

arterial hypertension, obesity, dyslipidemia, and insulin resistance. Scientific

evidence demonstrates that the pathogenesis of PCOS involves a state of chronic

low-grade systemic inflammation, manifested by elevated serum levels of

inflammatory cytokines and repercussions on peripheral lymphocyte function. The

systemic impacts of this inflammation, resulting from the dysregulation of lymphocyte

subpopulations, occur independently of body mass index (BMI), affecting both

eutrophic women and those with overweight or obesity. The identification of

prognostic biomarkers is fundamental for understanding the pathophysiology of

chronic inflammation, as well as for monitoring the therapeutic response of the

syndrome. Preliminary results of this study evidence significant immunological and

inflammatory alterations in the PCOS group compared to the control group. A

significant increase was observed in T-lymphocyte subpopulations and the

expression of cellular activation markers, suggesting a robust immune response.

Specifically, elevations were verified in CD3/CD4 (p=0,031), 54,4% de CD8

(p=0,028), 92,8% de CD38 (p=0,009) e 81,4% and HLA-DR+ (p=0,012). Furthermore,

the systemic inflammatory profile corroborated a state of immune exacerbation. The

Neutrophil-to-Lymphocyte Ratio (NLR) showed a 33.3% increase (p=0,042) while the

Systemic Immune-Inflammation Index (SII) recorded a rise of 41.3% (p=0,0,38).

COMMITTEE MEMBERS:
Externo ao Programa - 2611909 - CARLOS RAMON DO NASCIMENTO BRITO - nullExterna ao Programa - 3075402 - DEYSE DE SOUZA DANTAS - nullPresidente - 1143827 - JULIANA FELIX DA SILVA