Banca de QUALIFICAÇÃO: KATIANE MIRELLE DA SILVA VALE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : KATIANE MIRELLE DA SILVA VALE
DATE: 31/10/2025
TIME: 08:00
LOCAL: https://meet.google.com/nek-adyy-jsr
TITLE:

ADAPTATION PROCESS OF SOLID PHARMACEUTICAL DOSAGE FORM IN NEONATAL ICU: DESCRIPTIVE STUDY AND EXPERIMENTAL SIMULATION WITH HYDROCHLOROTHIAZIDE TABLETS

 

KEY WORDS:

Neonatology; dosage form adaptation; hydrochlorothiazide; descriptive and experimental research.

PAGES: 122
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUBÁREA: Farmácia clínica, assistência e atenção farmacêuticas
SUMMARY:

Introduction: Most drugs used in Neonatal Intensive Care Units (NICUs) are not available in appropriate pharmaceutical forms and dosages for neonates, often resulting in frequent off-label or unlicensed use. In this context, the adaptation of tablets into extemporaneous liquid preparations is a common practice. However, this practice presents risks related to dose variation, stability, and safety, in addition to the lack of standardization in procedures. Objective: To investigate the occurrence and characteristics of hydrochlorothiazide tablet adaptations in neonatology, as well as to evaluate the accuracy and safety of these techniques under simulatedexperimental conditions. Methodology: The study was conducted in three complementary stages: (i) application of an electronic questionnaire to health professionals working in NICUs across hospitals in northeastern Brazil to map tablet adaptation practices; (ii) laboratory simulation of the reported techniques, using the same medical and hospital materials employed in clinical practice; (iii) physicochemical characterization of the resulting preparations, including quantification of the drug content. Results: Great variability between the techniques was identified, alongside limitations in dose accuracy and a risk of drug loss, which compromises therapeutic safety. Conclusion: Hydrochlorothiazide adaptations in neonatology result in wide dose variability due to the low solubility of the drug and the limitations of the evaluated techniques. No method guarantees adequate homogeneity, reinforcing the need for standardization and the development of customized formulations for neonates.

 

COMMITTEE MEMBERS:
Externo ao Programa - 3048067 - ANTONIO MANUEL GOUVEIA DE OLIVEIRA - nullExterno à Instituição - ROBERTO PONTAROLO - UFPR
Interna - 1754360 - WALDENICE DE ALENCAR MORAIS LIMA