Banca de QUALIFICAÇÃO: MATHEUS ANDRÉ COUTINHO FERREIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MATHEUS ANDRÉ COUTINHO FERREIRA
DATE: 17/12/2020
TIME: 09:00
LOCAL: Videoconferência
TITLE:

miRNA-Box: Hardware architecture to integrate a microRNA system detection

KEY WORDS:

cancer, miRNA, biomarker, embedded system, system-aided diagnosis

PAGES: 73
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

State of the art: Cancer, also known as malignant neoplasia, is a disease that is associated with disordered cell growth and can be quite aggressive and uncontrollable. The various types of cancer are associated with the variety of cells present in the human body, differentiating through the speed of cell multiplication and ability to attack tissues and organs.  Problem:  Specialized professionals and high-cost equipment are essential for the diagnosis. In underdeveloped or developing countries, the complexity to perform the diagnosis increases, due to the high demand of patients and the absence of quality analysis. However, new technologies and strategies that act directly in early diagnosis are being investigated. One of them is the use of miRNAs, which are key regulators of gene expression, a fact that associates the interaction of miRNAs with the genome and the onset of diseases, and can thus be used as a biomarker. Methodology:  A bibliographic study was conducted on cancer and the use of miRNAs as biomarkers, to then start the requirements gathering, in order to understand the needs that the system should address. From this, the prototyping was initialized to validate the requirements, as well as to present the visual identity of the project, in order to provide a good usability and user experience.  After this initial phase, the scrum framework was used, which is based on agile methodologies, for the planning and implementation of the embedded system. Results and discussions: This study provided support for the development of the embedded system that drives the hardware in order to perform the reading and quantification of miRNA residues in order to ensure high specificity, low cost and rapid execution, according to the criteria of applicability and scalability for the Unified Health System (SUS), besides having interoperability with the electronic patient's medical record (PEP), ensuring the optimization of information management to public health services, providing greater economics to the SUS. Conclusion: The  miRNA-Box, an embedded system used in a biomedical device, developed by the Advanced Center for Technological Innovation (NAVI) in partnership with the Laboratory of Technological Innovation in Health (LAIS) and the Ministry of Health (MS) proposes the applicability in Primary Health Care (PHC) with the objective of performing the analysis and early diagnosis of breast, prostate and cervical cancer, in order to improve the screening process of patients and provide cost reduction in the health area with complex diseases.

BANKING MEMBERS:
Presidente - 046.446.184-70 - ANTONIO HIGOR FREIRE DE MORAIS - IFRN
Externo à Instituição - JAILTON CARLOS DE PAIVA - IFRN
Interno - 010.655.474-39 - JOÃO PAULO QUEIROZ DOS SANTOS
Externo à Instituição - LEONARDO JUDSON GALVAO DE LIMA