Banca de DEFESA: JULIANA MENDONCA FREIRE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: JULIANA MENDONCA FREIRE
DATA: 10/06/2015
HORA: 14:00
LOCAL: CONSEC - CCS
TÍTULO:

Analise das características clÍnicas, hematológicas e do perfil de expressão antigênica de pacientes com leucemia mielóide aguda do estado de Rio Grande do Norte.


PALAVRAS-CHAVES:

Leucemia Mielóide Aguda, Parâmetros hematológicos, imunofenotipagem.


PÁGINAS: 80
GRANDE ÁREA: Ciências da Saúde
ÁREA: Medicina
RESUMO:

Acute leukemias are a heterogeneous group of hematologic diseases characterized by rapid and abnormal proliferation of blood precursors in the bone marrow. The objective of this study was to analyze a group of 338 patients with Acute Myeloid Leukemia (AML), based on morphological, clinical and immunophenotypic criteria by flow cytometry, as well as investigate the correlation between these data and the subtypes of AML. Of the 338 patients studied, 182 (53.8 %) were male and 156 patients (46.2%) females, aged 1-90 years. The splenomegaly was predominant clinical manifestations compared with 270 cases. Leukocytosis was present in 298 (88.1 %) and 302 (89.3 %) had platelet counts below 100.000/mm3. Hemoglobin ranged from 2.5g/dL the 12g/dL. Regarding the subtypes of AML, 4 (1.2 %) were AML - M0, 110 (32.5 %) were AML - M1, 82 (24.3 %) AML - M2, 38 (11.2 %) AML - M3, 53 (15.7 %) AML -M4, 35 (10.3 %) AML -M5 9 (2.7 %) AML -M6 and 7 (2.1 %) AML-M7. The expression of aberrant phenotypes was observed with positivity for lymphoid antigens such as CD7 in 34 (10.6 %) patients and CD19, present in 22 (6:53 %). The analysis of the worldwide incidence of leukemia subtypes showed significant changes in relation to the geographical distribution, gender, age, ethnicity and socioeconomic status , suggesting that there are multiple etiological factors. These data demonstrate the importance of differential diagnosis and characterization of AML to provide better treatment and monitoring of this neoplasm.


MEMBROS DA BANCA:
Externo à Instituição - AMALIA CINTHIA MENESES DO REGO - UnP
Presidente - 6349161 - GERALDO BARROSO CAVALCANTI JUNIOR
Externo ao Programa - 347667 - MARIA GORETTI DO NASCIMENTO SANTOS
Notícia cadastrada em: 23/06/2014 09:36
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