Banca de QUALIFICAÇÃO: MARCIA DE OLIVEIRA PEREIRA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE: MARCIA DE OLIVEIRA PEREIRA
DATA: 21/06/2013
HORA: 10:00
LOCAL: SALA DE AULA 1 - PPGCSA
TÍTULO:

Influence of whole-body vibration on biodistribution of the radiopharmaceutical [99mTc]methylene diphosphonate in Wistar rats


PALAVRAS-CHAVES:

Whole-body vibration, [99mTc]MDP, Biodistribution


PÁGINAS: 56
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Aim:The radionuclide bone scan is the basis of skeletal nuclear medicine imaging. Bone scintigraphy is a highly sensitive method for indicating disease in bone, often providing earlier diagnosis or demonstrating more lesions than are found by conventional radiol ogical methods. Mechanical stimulation in the manner of whole-body vibration (WBV) appears beneficial to the maintenance and/or enhancement of skeletal mass in individuals such as the elderly, postmenopausal women, and adolescents. Therefore, this may be an effective method by which therapy may be administered to mobilitylimited individuals without the risks associated with high -impact exercise. The objective of this work was to evaluate the effect of WBV on biodistribution of the radiopharmaceutical [99mTc]methylene diphosphonate ([99mTc]MDP) in Wistar rats.
Methods: In the biodistribution analysis, Wistar rats were anesthetized with sodium thiopental, the radiopharmaceutical [99mTc]MDP was administrated via ocular plexus and after 10 min the animals were submitted to vibration of 20Hz per 1 minute in an oscillatory platform. Following, the animals were sacrificed, the organs were isolated, the radioactivity determined in a well counter, and the percentages of radioactivity per gram (%ATI/g) in the organs were calculated. An unpaired t test following Welch test was done for statistical analysis of the results.
Results:The biodistribution was significantly (P<0.01) decreased in kidney, lung, prostate and bowel and significantly (P<0.05) increased in intestine and liver.
Conclusion:The analysis of the results indicates that the vibration could produce metabolic alterations with influence in the uptake of the radiopharmaceutical [99mTc]-MDP in kidney, bladder, prostate, bowel, and bone.


MEMBROS DA BANCA:
Presidente - 346138 - ALDO DA CUNHA MEDEIROS
Externo ao Programa - 6349165 - CECILIA MARIA DE CARVALHO XAVIER HOLANDA
Externo à Instituição - SEBASTIAO DAVID DOS SANTOS FILHO - UERJ
Notícia cadastrada em: 14/06/2013 10:00
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